SARS‐CoV‐2 Non-Structural Protein 1(NSP1) Mutation Virulence and Natural Selection: Evolutionary Trends in the Six Continents

26 Pages Posted: 20 Oct 2022

See all articles by Samira Salami Ghaleh

Samira Salami Ghaleh

University of Guilan

Karim Rahimian

Tarbiat Modares University

Mohammadamin Mahmanzar

University of Hawaii at Manoa

Bahar Mahdavi

Royan Institute

Samaneh Tokhanbigli

Islamic Azad University

Mahsa Mollapour Sisakht

Erasmus University Rotterdam (EUR)

Amin Farhadi

Payame Noor University

Mahsa Mousakhan Bakhtiari

Tehran University of Medical Sciences

Donna Lee Kuehu

University of Hawaii at Manoa

Youping Deng

University of Hawaii at Manoa - Department of Complementary and Integrative Medicine

Abstract

We analyzed about 6.5 million samples E87D as the most frequent mutation on NSP1 affects on destabilization of the virusE87D mutation has signed up to January 2022 as the first frequent mutation observed. H110Y and R24C are the second and third most frequent mutations, respectively.

Keywords: COVID-19, SARS-CoV-2, NSP1, mutations, translational inhibition, E87D

Suggested Citation

Ghaleh, Samira Salami and Rahimian, Karim and Mahmanzar, Mohammadamin and Mahdavi, Bahar and Tokhanbigli, Samaneh and Mollapour Sisakht, Mahsa and Farhadi, Amin and Bakhtiari, Mahsa Mousakhan and Kuehu, Donna Lee and Deng, Youping, SARS‐CoV‐2 Non-Structural Protein 1(NSP1) Mutation Virulence and Natural Selection: Evolutionary Trends in the Six Continents. Available at SSRN: https://ssrn.com/abstract=4246887 or http://dx.doi.org/10.2139/ssrn.4246887

Samira Salami Ghaleh

University of Guilan ( email )

P.O. Box 1841
Rasht
Iran

Karim Rahimian

Tarbiat Modares University ( email )

Jalal Ale Ahmad Highway
Tehran, 14115-111
Iran

Mohammadamin Mahmanzar

University of Hawaii at Manoa ( email )

Bahar Mahdavi

Royan Institute ( email )

Hafez St
Tehran, 0098
Iran

Samaneh Tokhanbigli

Islamic Azad University ( email )

Mahsa Mollapour Sisakht

Erasmus University Rotterdam (EUR) ( email )

Amin Farhadi

Payame Noor University ( email )

Iran

Mahsa Mousakhan Bakhtiari

Tehran University of Medical Sciences ( email )

Number 21, Dameshg St.
Vali-e Asr Ave.
Tehran, 14195
Iran

Donna Lee Kuehu

University of Hawaii at Manoa ( email )

Youping Deng (Contact Author)

University of Hawaii at Manoa - Department of Complementary and Integrative Medicine ( email )

651 Ilalo Street
HI 96813
United States

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