International Journal of Diabetes and Endocrinology

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Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah

Received: 12 November 2020    Accepted: 27 November 2020    Published: 04 December 2020
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Abstract

It is an essential to evaluate the potential biomarkers affecting the progression of disease in COVID-19 patients. Therefore, we investigated the relationship between Ferritin levels and hematological parameters and severity of COVID-19 to explore its role in predicting the severity of COVID-19. This retrospective study was conducted in different Hospitals at Madinah region, Saudi Arabia. In the present study, a total of 112 cases of COVID-19 patients. The patient records included the clinical and laboratory data that was used for analysis by using the GraphPad Prism Software. Data presented as mean (SD), all differences were statistically significant at the level of P≤0.05 or ≤0.001. There were significantly increased levels of ferritin, neutrophil and leukocyte counts in severe COVID-19 cases (1857 (50.9), 9.9 (2.8), 9.9 (2.8) respectively) compared with non-sever cases. Additionally, there were significantly reduction in lymphocytes counts in COVID-19 patients (1.3 (9.5), P=0.001). There were also strong correlations between elevation of ferritin levels or reduction of lymphocytes and the severity COVID-19 infection (r=0.53, OR: 5.88 and r=-0.55, OR: 3.98 respectively). The results demonstrate that high values for neutrophil, leukocyte counts and Ferritin levels, and low values for lymphocyte counts may have diagnostic properties concerning COVID-19 in severe cases.

DOI 10.11648/j.ijde.20200504.12
Published in International Journal of Diabetes and Endocrinology (Volume 5, Issue 4, December 2020)
Page(s) 61-66
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Neutrophil, Leukocyte, Ferritin, Lymphocyte, COVID-19

References
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Author Information
  • Medical Laboratory Science, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia

  • Family and Community Medicine, College of Medicine, Taibah University, Madinah, Saudi Arabia

  • Department of Internal Medicine, Ohud Hospital, Madinah, Saudi Arabia

  • Department of Internal Medicine, Madinah General Hospital, Madinah, Saudi Arabia

  • Medical Laboratory Science, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia

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  • APA Style

    Walaa Mohammedsaeed, Amal M. Surrati, Hadiah Q. Alnakhli, Malak Alharbi, Nidda Syeed. (2020). Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah. International Journal of Diabetes and Endocrinology, 5(4), 61-66. https://doi.org/10.11648/j.ijde.20200504.12

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    ACS Style

    Walaa Mohammedsaeed; Amal M. Surrati; Hadiah Q. Alnakhli; Malak Alharbi; Nidda Syeed. Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah. Int. J. Diabetes Endocrinol. 2020, 5(4), 61-66. doi: 10.11648/j.ijde.20200504.12

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    AMA Style

    Walaa Mohammedsaeed, Amal M. Surrati, Hadiah Q. Alnakhli, Malak Alharbi, Nidda Syeed. Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah. Int J Diabetes Endocrinol. 2020;5(4):61-66. doi: 10.11648/j.ijde.20200504.12

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  • @article{10.11648/j.ijde.20200504.12,
      author = {Walaa Mohammedsaeed and Amal M. Surrati and Hadiah Q. Alnakhli and Malak Alharbi and Nidda Syeed},
      title = {Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah},
      journal = {International Journal of Diabetes and Endocrinology},
      volume = {5},
      number = {4},
      pages = {61-66},
      doi = {10.11648/j.ijde.20200504.12},
      url = {https://doi.org/10.11648/j.ijde.20200504.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijde.20200504.12},
      abstract = {It is an essential to evaluate the potential biomarkers affecting the progression of disease in COVID-19 patients. Therefore, we investigated the relationship between Ferritin levels and hematological parameters and severity of COVID-19 to explore its role in predicting the severity of COVID-19. This retrospective study was conducted in different Hospitals at Madinah region, Saudi Arabia. In the present study, a total of 112 cases of COVID-19 patients. The patient records included the clinical and laboratory data that was used for analysis by using the GraphPad Prism Software. Data presented as mean (SD), all differences were statistically significant at the level of P≤0.05 or ≤0.001. There were significantly increased levels of ferritin, neutrophil and leukocyte counts in severe COVID-19 cases (1857 (50.9), 9.9 (2.8), 9.9 (2.8) respectively) compared with non-sever cases. Additionally, there were significantly reduction in lymphocytes counts in COVID-19 patients (1.3 (9.5), P=0.001). There were also strong correlations between elevation of ferritin levels or reduction of lymphocytes and the severity COVID-19 infection (r=0.53, OR: 5.88 and r=-0.55, OR: 3.98 respectively). The results demonstrate that high values for neutrophil, leukocyte counts and Ferritin levels, and low values for lymphocyte counts may have diagnostic properties concerning COVID-19 in severe cases.},
     year = {2020}
    }
    

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    T1  - Alteration of Ferritin Levels and Lymphocytes Counts in Saudi Patients with COVID-19 Infection in Al Madinah Al Munawarah
    AU  - Walaa Mohammedsaeed
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    JO  - International Journal of Diabetes and Endocrinology
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    PB  - Science Publishing Group
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    AB  - It is an essential to evaluate the potential biomarkers affecting the progression of disease in COVID-19 patients. Therefore, we investigated the relationship between Ferritin levels and hematological parameters and severity of COVID-19 to explore its role in predicting the severity of COVID-19. This retrospective study was conducted in different Hospitals at Madinah region, Saudi Arabia. In the present study, a total of 112 cases of COVID-19 patients. The patient records included the clinical and laboratory data that was used for analysis by using the GraphPad Prism Software. Data presented as mean (SD), all differences were statistically significant at the level of P≤0.05 or ≤0.001. There were significantly increased levels of ferritin, neutrophil and leukocyte counts in severe COVID-19 cases (1857 (50.9), 9.9 (2.8), 9.9 (2.8) respectively) compared with non-sever cases. Additionally, there were significantly reduction in lymphocytes counts in COVID-19 patients (1.3 (9.5), P=0.001). There were also strong correlations between elevation of ferritin levels or reduction of lymphocytes and the severity COVID-19 infection (r=0.53, OR: 5.88 and r=-0.55, OR: 3.98 respectively). The results demonstrate that high values for neutrophil, leukocyte counts and Ferritin levels, and low values for lymphocyte counts may have diagnostic properties concerning COVID-19 in severe cases.
    VL  - 5
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