Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-17T08:57:20.880Z Has data issue: false hasContentIssue false

Increased incidence of idiopathic paediatric facial palsy during the coronavirus disease 2019 pandemic

Published online by Cambridge University Press:  12 May 2021

E S Hogg*
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
T Hampton
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
I Street
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
R Clarke
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
K Wright
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
S De
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
S D Sharma
Affiliation:
Department of ENT, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
*
Author for correspondence: Miss E S Hogg, Department of ENT, Alder Hey Children's NHS Foundation Trust, Eaton Road, LiverpoolL12 2AP, UK E-mail: e.hogg2@nhs.net

Abstract

Background

Bell's palsy is a lower motor neurone facial weakness of unknown aetiology, although reactivation of a virus within the facial nerve has been proposed.

Methods

A prospective study was conducted of Bell's palsy cases presenting to our paediatric ENT unit over a 19-week period, from February to June 2020. Patients were invited for severe acute respiratory syndrome coronavirus-2 antibody testing. A text-message questionnaire was sent to other ENT centres to determine their observational experience.

Results

During the study period, 17 children presented with Bell's palsy, compared with only 3 children in the same time period in the previous year (p < 0.0001). Five patients underwent severe acute respiratory syndrome coronavirus-2 antibody testing, the results of which were all negative. Four out of 15 centres questioned perceived an increased incidence in paediatric Bell's palsy.

Conclusion

Clinicians are encouraged to be vigilant to the increase in paediatric Bell's palsy seen during the coronavirus disease 2019 pandemic, which may represent a post-viral sequela of coronavirus disease 2019.

Type
Main Articles
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Miss E S Hogg takes responsibility for the integrity of the content of the paper

References

Khan, A, Hussain, N, Gosalakkal, J. Bells palsy in children – a review. J Pediatr Sci 2011;3:77Google Scholar
Baugh, RF, Basura, GJ, Ishii, LE, Schwartz, SR, Drumheller, CM, Burkholder, R et al. Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg 2013;149(3 suppl):127CrossRefGoogle ScholarPubMed
Fang, Q, Wan, Y, Cao, S, Wang, M, Huang, Y. Coronavirus disease 2019 complicated with Bell's palsy: a case report. Neurology 2020. Epub 2020 Apr 16Google Scholar
Viner, RM, Whittaker, E. Kawasaki-like disease: emerging complication during the COVID-19 pandemic. Lancet 2020;395:1741–3CrossRefGoogle ScholarPubMed
Verdoni, L, Mazza, A, Gervasoni, A, Martelli, L, Ruggeri, M, Ciuffreda, M et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet 2020;395:1771–8CrossRefGoogle Scholar
Health Research Authority. Decision Tool. In: http://www.hra-decisiontools.org.uk/research/ [5 May 2021]Google Scholar
Mao, L, Jin, H, Wang, M, Hu, Y, Chen, S, He, Q et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683–90CrossRefGoogle ScholarPubMed
NHS. Symptoms of coronavirus (COVID-19). In: https://www.nhs.uk/conditions/coronavirus-covid-19/symptoms/#symptoms [13 November 2020]Google Scholar
ENT UK. Advice for patients with new-onset anosmia during COVID-19 pandemic. In: https://www.entuk.org/advice-patients-new-onset-anosmia-during-covid-19-pandemic [5 May 2021]Google Scholar
Goh, Y, Beh, DL, Makmur, A, Somani, J, Chan, AC. Pearls and oy-sters: facial nerve palsy as a neurological manifestation of Covid-19 infection. Neurology 2020;95(suppl 8):364–7CrossRefGoogle ScholarPubMed
Sedaghat, Z, Karimi, N. Guillain Barre syndrome associated with COVID-19 infection: a case report. J Clin Neurosci 2020;76:233–5CrossRefGoogle ScholarPubMed
Toscano, G, Palmerini, F, Ravaglia, S, Ruiz, L, Invernizzi, P, Cuzzoni, MG et al. Guillain–Barré syndrome associated with SARS-CoV-2. N Engl J Med 2020;382:2574–6CrossRefGoogle ScholarPubMed
Lima, MA, Silva, MT, Soares, CN, Coutinho, R, Oliveira, HS, Afonso, L et al. Peripheral facial nerve palsy associated with COVID-19. J Neurovirol 2020;26:941–4CrossRefGoogle ScholarPubMed
Zammit, M, Markey, A, Webb, C. A rise in facial nerve palsies during the coronavirus disease 2019 pandemic. J Laryngol Otol 2020;134:905–8CrossRefGoogle Scholar
Tosif, S, Neeland, MR, Sutton, P, Licciardi, PV, Sarkar, S, Selva, KJ et al. Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19. Nat Commun 2020;11:5703CrossRefGoogle ScholarPubMed
Zhang, W, Xu, L, Luo, T, Wu, F, Zhao, B, Li, X. The etiology of Bell's palsy: a review. J Neurol 2020;267:1896–905CrossRefGoogle ScholarPubMed
Ward, H, Cooke, G, Atchison, CJ, Whitaker, M, Elliott, J, Moshe, M et al. Declining prevalence of antibody positivity to SARS-CoV-2: a community study of 365,000 adults. medRxiv 2020.10.26.20219725Google Scholar
Weisberg, SP, Connors, TJ, Zhu, Y, Baldwin, MR, Lin, WH, Wontakal, S et al. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum. Nat Immunol 2021;22:2531CrossRefGoogle ScholarPubMed