Med
Volume 1, Issue 1, 18 December 2020, Pages 14-20
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Commentary
Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation

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The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.

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