Drug Fever Due to Favipiravir Administration for the Treatment of a COVID-19 Patient

Junsuke Tawara; Takanori Uehara; Seiichiro Sakao; Hidetoshi Igari; Toshibumi Taniguchi; Hajime Kasai; Shin Takayanagi; Misuzu Yahaba; Ryo Shimada; Masatomi Ikusaka

doi:10.2169/internalmedicine.5813-20

This article has now been updated. Please use the final version.

Drug Fever Due to Favipiravir Administration for the Treatment of a COVID-19 Patient

Junsuke Tawara, Takanori Uehara, Seiichiro Sakao, Hidetoshi Igari, Toshibumi Taniguchi, Hajime Kasai, Shin Takayanagi, Misuzu Yahaba, Ryo Shimada, Masatomi Ikusaka

Author information

Junsuke Tawara
Department of General Medicine, Chiba University Hospital, Japan
Takanori Uehara
Department of General Medicine, Chiba University Hospital, Japan
Seiichiro Sakao
Department of Respiratory Medicine, Chiba University Hospital, Japan
Hidetoshi Igari
Department of Infectious Diseases, Chiba University Hospital, Japan
Toshibumi Taniguchi
Department of Infectious Diseases, Chiba University Hospital, Japan
Hajime Kasai
Department of Respiratory Medicine, Chiba University Hospital, Japan
Shin Takayanagi
Department of Infectious Diseases, Chiba University Hospital, Japan
Misuzu Yahaba
Department of Infectious Diseases, Chiba University Hospital, Japan
Ryo Shimada
Department of General Medicine, Chiba University Hospital, Japan
Masatomi Ikusaka
Department of General Medicine, Chiba University Hospital, Japan

Keywords: COVID-19, favipiravir, drug fever, hyperuricemia

JOURNAL OPEN ACCESS Advance online publication

Article ID: 5813-20

DOI https://doi.org/10.2169/internalmedicine.5813-20

The final version of this article is now available: Vol. 60 (2021), No. 7 pp. 1115-1117

Details

Abstract

A 55-year-old Japanese man was hospitalized with the novel coronavirus disease. On the 13th day after the start of favipiravir administration, the patient developed a fever with a temperature of 38.1°C. His pulse rate also became elevated to 128 bpm, so relative bradycardia was not suspected. Since he was in good overall health and no concomitant symptoms and signs were apparent, we considered it to be drug fever due to favipiravir. After the completion of favipiravir treatment, the patient's temperature normalized within 24 hours. We herein report this case of drug fever caused by favipiravir.

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