Elsevier

Gene Reports

Volume 27, June 2022, 101619
Gene Reports

Therapeutic approaches and vaccination in fighting COVID-19 infections: A review

https://doi.org/10.1016/j.genrep.2022.101619Get rights and content

Highlights

  • The SARS-CoV-2 virus caused Coronavirus Disease 2019 (COVID-19), initially occurred in Wuhan, China.

  • COVID-19 outbreak started in China, resulting in a pandemic in several countries.

  • Up to this point, the Food and Drug Administration (FDA) has only approved one medication for COVID-19 (Remdesivir).

  • A variety of therapy approaches are available to prevent the disease from spreading and to reduce morbidity and mortality.

  • The current article reviews the most up-to-date information about the COVID-19 treatment and/or vaccine’s availability.

Abstract

Coronavirus disease 2019 (COVID-19) is a remarkably contagious and pathogenic viral infection arising from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first appeared in Wuhan, China. For the time being, COVID-19 is not treated with a specific therapy. The Food and Drug Administration (FDA) has approved Remdesivir as the first drug to treat COVID-19. However, many other therapeutic approaches are being investigated as possible treatments for COVID-19. As part of this review, we discussed the development of various drugs, their mechanism of action, and how they might be applied to different cases of COVID-19 patients. Furthermore, this review highlights an update in the emergence of new prophylactic or therapeutic vaccines against COVID-19. In addition to FDA or The World Health Organization (WHO) approved vaccines, we intended to incorporate the latest published data from phase III trials about different COVID-19 vaccines and provide clinical data released on the networks or peer-review journals.

Abbreviations

ACE2
Angiotensin-converting enzyme 2
Arb
Arbidol
ARDS
Acute respiratory distress syndrome
COVID-19
Coronavirus disease 2019
ER
Endoplasmic reticulum
ERGIC
Endoplasmic reticulum Golgi intermediate compartment
FDA
Food and Drug Administration
gRNA
Genomic RNA
HIV
Human immunodeficiency virus
mAbs
Monoclonal antibodies
MERS-CoV
The Middle East respiratory syndrome 20 coronavirus
ORFs
Open reading frames
RBD
Receptor binding domain
RdRp
RNA-dependent RNA polymerase
RTC
Replicase transcriptase complex
SARS-CoV-2
Severe acute respiratory syndrome of coronavirus 2
sgRNA
Subgenomic RNA
VLPs
Virus-like particles
WHO
World Health Organization
WMT
Washed microbiota transplantation

Keywords

Antiviral agents
COVID-19
Pandemics
Pneumonia
SARS-CoV-2
Vaccines

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