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Correspondence
Correspondence on ‘Preliminary predictive criteria for COVID-19 cytokine storm’
  1. Desiree Tampe1,
  2. Martin S Winkler2,
  3. Peter Korsten1,
  4. Samy Hakroush3,
  5. Onnen Moerer2,
  6. Björn Tampe1
  1. 1 Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany
  2. 2 Department of Anesthesiology, Emergency and Intensive Care Medicine, University Medical Center Göttingen, Göttingen, Germany
  3. 3 Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany
  1. Correspondence to Dr Björn Tampe, Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany; bjoern.tampe{at}med.uni-goettingen.de

https://doi.org/10.1136/annrheumdis-2020-219709

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    We read with great interest the recent article by Caricchio et al reporting preliminary predictive criteria for COVID-19 cytokine storm (COVID-CS).1 Early risk stratification for disease course and mortality is important especially in critically ill patients with severe COVID-19 to guide physicians in their evaluation to define patients at risk not surviving COVID-19 who may benefit from specific interventions.2 To develop a predictive model, the authors used univariate logistic regressions to identify variables and clusters associated with COVID-CS, resulting in defined optimal cut-off values.1 The model identified patients at risk for COVID-CS, associated with longer hospitalisation and increased mortality. While ferritin and C-reactive protein (CRP) did not add predictive power, these parameters were included in the final criteria per expert preference for clinical reassurance of ongoing systemic inflammation. Therefore, we here describe the performance of the COVID-CS predictive model for the requirement of intensive care unit (ICU) supportive care and mortality in a single-centre cohort of 20 critically ill patients with confirmed SARS-CoV-2 …

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    Footnotes

    • Twitter @pekor002

    • Contributors DT and BT conceived the letter, collected and analysed data, and cowrote the first draft. MSW, PK, SH, PK and OM participated in the construction and editing of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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