Issue 17, 2023

Efficient dispersive solid-phase extraction of methylprednisolone from exhaled breath of COVID-19 patients

Abstract

In the current study, bismuth ferrite nano-sorbent was synthesized and utilized as a sorbent for the dispersive solid-phase extraction of methylprednisolone from exhaled breath samples. The size and morphology of the nano-sorbent were characterized by X-ray diffraction analysis and scanning electron microscopy. Following its desorption with acetonitrile, methylprednisolone was quantified by a high-performance liquid chromatography-ultraviolet detector. Factors affecting the extraction of methylprednisolone were optimized. Under optimized experimental conditions, a linear relationship between the analytical signals and methylprednisolone concentration was obtained in the range of 0.001–0.2 μg mL−1 for exhaled breath condensate samples and 0.002–0.4 μg per filter for filter samples. A pre-concentration factor of 6.4-fold, corresponding to an extraction recovery of 96.0%, was achieved. The validated method was applied for the determination of methylprednisolone in real samples taken from the exhaled breath of COVID-19 patients under mechanical ventilation.

Graphical abstract: Efficient dispersive solid-phase extraction of methylprednisolone from exhaled breath of COVID-19 patients

Supplementary files

Article information

Article type
Paper
Submitted
11 Dec 2022
Accepted
28 Mar 2023
First published
12 Apr 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 11457-11463

Efficient dispersive solid-phase extraction of methylprednisolone from exhaled breath of COVID-19 patients

Y. Sefid-Sefidehkhan, M. Mokhtari, A. Mahmoodpoor, Y. Vaez-Gharamaleki, M. Khoubnasabjafari, M. R. Afshar Moghaddam, V. Jouyban-Gharamaleki, S. Dastmalchi, E. Rahimpour and A. Jouyban, RSC Adv., 2023, 13, 11457 DOI: 10.1039/D2RA07902J

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