D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1
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Graphical abstract
Abbreviations
ARL6IP6
ADP Ribosylation Factor Like GTPase 6 interacting protein 6
ASC
Apoptosis associated speck-like protein containing a caspase recruitment domain
BLAST
Basic Local Alignment Search Tool
CD4+
Cluster of Differentiation 4+
CD8+
Cluster of Differentiation 8+
COVID-19
Coronavirus Disease 2019
Cryo-EM
Cryo Electron Microscope
HMOX1
Heme Oxygenase 1
IFN
Interferon
MERS-CoV
Middle East respiratory syndrome coronavirus
MMGBSA
Molecular mechanics with generalized Born and surface area solvation
NCBI
National Centre for Biotechnology Information
NF-B
Nuclear factor kappa light chain enhancer of activated B cells
NLRP3
Nucleotide-binding oligomerization domain, Leucine rich repeat and Pyrin domain containing
ORF
Open Reading Frame
PDB
Protein Data Bank
PISA
Protein Interfaces Surfaces and Assemblies
PROVEAN
Protein Variation Effect Analyzer
RMSD
Root Mean Square Deviation
SUN2
SUN domain-containing protein 2
TRIM59
Tripartite motif-containing protein 59.
Keywords
ORF3a
SARS-CoV-2
Molecular dynamics simulation
Graph theory
Mutation
Caveolin-1
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The authors equally contributed to this paper.
© 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.