Platelet Index in Patients with Confirmed Coronavirus Disease 2019 Cases

Authors

  • Haerani Harun Department of Clinical Pathology, Faculty of Medicine, Tadulako University, Palu, Indonesia
  • Christin Rony Nayoan Department of Otorhinolaryngology, Faculty of Medicine, Tadulako University, Palu, Indonesia
  • Ipfi White Department of Obstetrics-Gynecology, Faculty of Medicine, Tadulako University, Palu, Indonesia
  • Nur Syamsi Department of Pharmacology, Faculty of Medicine, Tadulako University, Palu, Indonesia
  • Andi Alfia Mutmainnah Tanra Department of Pharmacology, Faculty of Medicine, Tadulako University, Palu, Indonesia
  • Sarifuddin Sarifuddin Department of Anatomy, Faculty of Medicine, Tadulako University, Palu, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7743

Keywords:

Platelet index, Platelet count, Mean platelet volume, Platelet crit, Coronavirus disease 2019

Abstract

BACKGROUND: Changes found on hematological examination are a helpful modality for assessing coronavirus disease 2019 (COVID-19). In addition, platelet index is a parameter that can help in assessing the COVID-19 disease prognosis.

AIM: Objective of the study is to determine the difference in platelet index in nucleid acid amplification test (NAAT) confirmed COVID-19 patients, suspected COVID-19 with negative NAAT results, and non-COVID-19 controls.

METHODS: This is an analytical observational study with 96 subjects; 48 subjects with confirmed COVID-19, 23 subjects suspected COVID-19 with negative NAAT results, and 24 non-COVID-19 control subjects. First, NAAT examination was carried out using the GeneXpert tool with the target genes of the E and N2 genes. Then, the platelet index was compared between the three groups by the Kruskal-Wallis test.

RESULTS: There was no significant difference in the number of platelet (PLT), mean PLT volume (MPV), and PLT crit (PCT) between the three groups with p = 0.732, 0.741 and 0.483, respectively. In general, the number of PLT, MPV, and PCT in the three groups was within the normal reference value.

CONCLUSIONS: There were no significant differences observed in the number of PLT, MPV, and PCT between COVID-19 patients with positive NAAT, COVID-19 suspects with negative NAAT, and non-COVID-19 controls. Therefore, detecting the severe acute respiratory syndrome coronavirus 2 virus by NAAT examination in COVID-19 patients has not altered the PLT index changes.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel Coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. https://doi.org/10.1016/S0140-6736(20)30183-5 PMid:31986264 DOI: https://doi.org/10.1016/S0140-6736(20)30183-5

Liao D, Zhou F, Luo L, Xu M, Wang H, Xia J, et al. Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: A retrospective cohort study. Lancet Haematol. 2020;7(9):e671-e8. https://doi.org/10.1016/S2352-3026(20)30217-9 Mid:32659214 DOI: https://doi.org/10.1016/S2352-3026(20)30217-9

Li Q, Cao Y, Chen L, Wu D, Yu J, Wang H, et al. Hematological features of persons with COVID-19. Leukemia. 2020;34(8):2163-72. https://doi.org/10.1038/s41375-020-0910-1 PMid:32528042 DOI: https://doi.org/10.1038/s41375-020-0910-1

Harun H, Bahrun U, Darmawaty E. Platelet-lymphocyte ratio (PLR) markers in acute coronary syndrome. Indones J Clin Pathol Med Lab. 2016;23:7-11. DOI: https://doi.org/10.24293/ijcpml.v23i1.1176

van der Meijden PE, Heemskerk JW. Platelet biology and functions: New concepts and clinical perspectives. Nat Rev Cardiol. 2019;16:166-79. https://doi.org/10.1038/s41569-018-0110-0 PMid:30429532 DOI: https://doi.org/10.1038/s41569-018-0110-0

Comer SP, Cullivan S, Szklanna PB, Weiss L, Cullen S, Kelliher S, et al. COVID-19 Induces a Hyperactive Phenotype in Circulating Platelets, medRxiv; 2020. https://doi.org/10.1101/2020.07.24.20156240 DOI: https://doi.org/10.1101/2020.07.24.20156240

Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, et al. Platelet gene expression and function in patients with COVID-19. Blood. 2020;136(11):1317-29. https://doi.org/10.1182/blood.2020007214 PMid:32573711 DOI: https://doi.org/10.1182/blood.2020007214

Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020;215:108427. https://doi.org/10.1016/j.clim.2020.108427 PMid:32325252 DOI: https://doi.org/10.1016/j.clim.2020.108427

Parasher A. COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J. 2021;97(1147):312-20. https://doi.org/10.1136/postgradmedj-2020-138577 PMid:32978337 DOI: https://doi.org/10.1136/postgradmedj-2020-138577

Kim JK, Jeon JS, Kim JW, Kim GY. Correlation between abnormal platelet count and respiratory viral infection in patients from Cheonan, Korea. J Clin Lab Anal. 2016;30(3):185-9. https://doi.org/10.1002/jcla.21822 PMid:25545354 DOI: https://doi.org/10.1002/jcla.21822

Chabert A, Hamzeh-Cognasse H, Pozzetto B, Cognasse F, Schattner M, Gomez RM, et al. Human platelets and their capacity of binding viruses: Meaning and challenges? BMC Immunol. 2015;16:26. https://doi.org/10.1186/s12865-015-0092-1 PMid:25913718 DOI: https://doi.org/10.1186/s12865-015-0092-1

Assinger A. Platelets and infection-an emerging role of platelets in viral infection. Front Immunol. 2014;5:649. https://doi.org/10.3389/fimmu.2014.00649 PMid:25566260 DOI: https://doi.org/10.3389/fimmu.2014.00649

Wool GD, Miller JL. The impact of COVID-19 disease on platelets and coagulation. Pathobiology. 2021;88(1):15-27. https://doi.org/10.1159/000512007 PMid:33049751 DOI: https://doi.org/10.1159/000512007

Güçlü E, Kocayiğit H, Okan HD, Erkorkmaz U, Yürümez Y, Yaylacı S, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras (1992). 2020;66(8):1122-7. https://doi.org/10.1590/1806-9282.66.8.1122 PMid:32935808 DOI: https://doi.org/10.1590/1806-9282.66.8.1122

Gumus H, Demir A, Yükkaldıran A. Is mean platelet volume a predictive marker for the diagnosis of COVID-19 in children? Int J Clin Pract. 2021;75(4):e13892. https://doi.org/10.1111/ijcp.13892 PMid:3328021 DOI: https://doi.org/10.1111/ijcp.13892

CDC. COVID-19 Resources and Guidelines for Labs and Laboratory Workers. Atlanta, Georgia, United States: Centers for Disease Control and Prevention; 2020. Available form: https://www.cdc.gov/coronavirus/2019-ncov/lab/naats.html [Last accessed on 2021 Sep 10].

Wang H, Li G, Zhao J, Li Y, Ai Y. An overview of nucleic acid testing for the novel coronavirus SARS-CoV-2. Front Med (Lausanne). 2020;7:571709. https://doi.org/10.3389/fmed.2020.571709 PMid:33537322 DOI: https://doi.org/10.3389/fmed.2020.571709

Pan American Health Organization. Interpretation of Laboratory Results for COVID-19 Diagnosis. Washington, DC, United States: Pan American Health Organization; 2020.

Renshaw AA, Drago B, Toraya N, Gould EW.Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume. Int J Infect Dis. 2013;17(9):e678-80. https://doi.org/10.1016/j.ijid.2013.01.012 PMid:23485431 DOI: https://doi.org/10.1016/j.ijid.2013.01.012

Hu Y, Lou Y, Chen Y, Mao W. Evaluation of mean platelet volume in patients with hepatitis B Virus infection. Int J Clin Exp Med. 2014;7(11):4207-13. PMid:25550932

Aksoy HT, Eras Z, Guzoglu N, Canpolat FE, Dilmen U. Mean platelet volume is not associated with bacterial sepsis in newborns. Int J Infect Dis. 2013;17(12):e1263. https://doi.org/10.1016/j.ijid.2013.05.010 PMid:23856507 DOI: https://doi.org/10.1016/j.ijid.2013.05.010

Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci. 2013;13(2):333-8. https://doi.org/10.4314/ahs.v13i2.19 PMid:24235932 DOI: https://doi.org/10.4314/ahs.v13i2.19

Alnor A, Sandberg MB, Toftanes BE, Vinholt PJ. Platelet parameters and leukocyte morphology is altered in COVID-19 patients compared to non-COVID-19 patients with similar symptomatology. Scand J Clin Lab Invest. 2021;81(3):213-7. https://doi.org/10.1080/00365513.2021.1894601 PMid:33685285 DOI: https://doi.org/10.1080/00365513.2021.1894601

Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, et al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 2020;31(4):490-6. https://doi.org/10.1080/09537104.2020.1754383 PMid:32297540 DOI: https://doi.org/10.1080/09537104.2020.1754383

Xu P, Zhou Q, Xu J. Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol. 2020;99(6):1205-8. https://doi.org/10.1007/s00277-020-04019-0 PMid:32296910 DOI: https://doi.org/10.1007/s00277-020-04019-0

Downloads

Published

2021-12-16

How to Cite

1.
Harun H, Nayoan CR, White I, Syamsi N, Tanra AAM, Sarifuddin S. Platelet Index in Patients with Confirmed Coronavirus Disease 2019 Cases. Open Access Maced J Med Sci [Internet]. 2021 Dec. 16 [cited 2024 Mar. 29];9(B):1705-9. Available from: https://oamjms.eu/index.php/mjms/article/view/7743

Issue

Section

Infective Diseases

Categories