Izvorni znanstveni članak
https://doi.org/10.26800/LV-144-supl3-5
Correlation between inflammatory parameters and bloodstream infections caused by multidrug resistant Gram-negative bacteria in critically ill COVID-19 patients – retrospective single-center study
Sanja Sakan
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Kristina Kralik
; Department of Medical Statistics and Medical Informatics,Medical Faculty Osijek, University Josip Juraj Strossmayer of Osijek, Osijek, Croatia
Antonija Mihelčić
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Sonja Hleb
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Vanja Blagaj
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Marcela Čučković
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Karolina Dobrović
; Department of Clinical Microbiology and Hospital Infection, University Hospital Dubrava, Zagreb, Croatia
Verica Mikecin
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Darko Kristović
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Marina Desnica
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Nataša Sojčić
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Nikola Bradić
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Andrej Šribar
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia, Šribar
Zrinka Šafarić Oremuš
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia
Jasminka Peršec
; Department of Anesthesiology, Reanimatology and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Prilozi: 00d_SADRZAJ.pdf
Sažetak
Objectives: During the COVID-19 pandemics we have seen in critically ill COVID-19 patients treated in the intensive care unit the parallel outbreak of multidrug resistant Gram-negative bacteria bloodstream infections, mainly Acinetobacter baumannii and Klebsiella pneumoniae. Methods: We conducted a retrospective cohort single-center study. The aim was to investigate the incidence, etiology and impact of intensive care unit bloodstream infections in COVID-19 patients admitted to the COVID-19 intensive care unit with a known burden of multidrug resistance and to evaluate the possibility that inflammatory parameters levels measured at two different time points of treatment can early predict multidrug resistant Gram-negative bacteria bloodstream infections and enable timely beginning of bacterial targeted antimicrobial therapy. Results: Our study confirmed that procalcitonin values of 2,46 mcg/L and neutrophil/lymphocyte ratio of 28,9 could be a reliable indicators for high risk stratification of multidrug resistant Gram-negative bacterial infection origin in critically ill COVID-19 patients (Mann Whitney U test, P=0,02). Conclusion: Monitoring dynamic shift of inflammatory parameters in critically ill COVID-19 patients could reliably help clinician to recognize the multidrug resistant Gram-negative bacteria bloodstream infections and start with the antimicrobial therapy in a timely manner.
Ključne riječi
COVID-19 PANDEMICS; GRAM-NEGATIVE BACTERIA; ACINETOBACTER BAUMANNII; KLEBSIELLA
Hrčak ID:
284146
URI
Datum izdavanja:
25.9.2022.
Posjeta: 909 *