Characteristics Of Clinical Symptoms In Pregnancy With Coronavirus Disease (Covid-19)

Illa Arinta* -  Akademi Kebidanan RSPAD Gatot Soebroto, Indonesia
Deviyana Nuraini -  Akademi Kebidanan RSPAD Gatot Soebroto, Indonesia
Alliah Nuranggraeni -  Akademi Kebidanan RSPAD Gatot Soebroto, Indonesia

Latar Belakang. Penyakit Coronavirus 2019 (COVID-19) merupakan penyakit yang saat ini mewabah hampir di seluruh dunia dan disebut Coronavirus-2 (SARS-COV2) dengan sindrom pernafasan akut yang parah. Pertama kali dilaporkan pada 31 Desember 2019, dari daerah Wuhan, provinsi Hubei, China, kasus pertama pneumonia tanpa penyebab yang diketahui. Data WHO per 7 Maret 2020 mengidentifikasi 90.870 kasus terkonfirmasi dengan total kematian 3.112 orang. Sampai dengan 22 Juli 2020, WHO telah melaporkan 14.971.036 kasus yang dikonfirmasi dengan 618.017 kematian di seluruh dunia (Case Fatality Rate/CFR 4,1%).

Tujuan. Diketahuinya Karakteristik gejala klinis pada kehamilan dengan Coronavirus Disease (COVID-19) di RSPAD Gatot Soebroto Periode Maret 2020 – Februari 2021”.

Metode. Jenis penelitian kuantitatif dengan deskriptif analitik dengan pendekatan retrospektif secara cross sectional, lokasi penelitian dilaksanakan di Poli Fetomaternal RSPAD Gatot Soebroto Jakarta Pusat pada bulan Maret 2020 – Februari 2021. Populasi 201 ibu hamil yang melakukan kunjungan ANC, sampel 75 ibu hamil dengan covid, instrumen yang digunakan adalah data dari rekam medik. Variabel yang digunakan adalah usia, paritas, usia kehamilan, penyakit penyerta kehamilan, derajat Covid-19.

Hasil. Usia ibu paling banyak antara usia 24 tahun sebesar 6 orang (8%), usia 28 tahun sebesar 8 orang (10,7%), usia 30 tahun sebesar 8 orang (10,7%), usia 34 tahun sebesar 6 orang (8%), usia 39 tahun sebesar 6 orang (8%), dengan usia minimal 21 tahun dan usia maksimal 42 tahun, dari 75 ibu hamil dengan covid. Ibu hamil dengan covid usia beresiko sebesar 15 orang (20%), dan ibu hamil dengan covid usia tidak beresiko sebesar 60 orang (80%). Terdapat multigravida sebesar 59 orang (78,7%), sedangkan primigravida sebesar 16 orang (21,3%). Usia kehamilan aterm sebanyak 72 (96.0%), sebagian kecil usia kehamilan preterm 3 (4%) Penyakit penyerta kehamilan pada ibu hamil dengan covid-19 rata-rata tidak memiliki penyakit penyerta, penyakit penyerta kehamilan yang paling banyak adalah PEB 8 (10.7), HbSag (+) sebesar 3 (4%), dan asma sebesar 2 (2.7%). Derajat covid-19 pada ibu hamil mayoritas adalah derajat ringan 63 (84.0%), serajat berat hanya 3 (4%).

Kesimpulan. Hasil penelitian melalui telaah literatur review menunjukan ibu hamil berusia 28 dan 30 tahun merupakan usia ibu hamil terbanyak yaitu sebesar 10,7%, sebagian besar ibu hamil berjumlah 59 orang merupakan multigravida yaitu sebesar 78,7%, sebagian besar ibu hamil berjumlah 72 orang berada pada usia kehamilan aterm sebesar 96,0%, penyakit penyerta ibu hamil paling banyak adalah PEB berjumlah 8 orang sebesar 10,7%, serta derajat covid-19 pada ibu hamil  mayoritas merupakan derajat ringan sejumlah 63 orang dan berjumlah 84,0%.

Saran Derajat covid-19 pada ibu hamil mayoritas adalah derajat ringan 63 (84.0%), serajat berat hanya 3 (4%), maka saat disarankan untuk ISOMAN prosedur pemulangan pasien saat ibu hamil dinyatakan boleh ISOMAN maka rumah sakit menyusun prosedur pemulangan pasien hamil dengan covid yang dapat menularkan meskipun dengan gejala ringan.

 

Kata kunci: Covid-19, Ibu hamil, derajat Covid-19. penyakit penyerta kehamilan, usia, paritas, usia kehamilan

 

ABSTRACT

 

 

Background. Coronavirus disease 2019 (COVID-19) is currently endemic almost all over the world and is called Coronavirus-2 (SARS-COV2) with the severe acute respiratory syndrome. It was first reported on December 31, 2019, from Wuhan, China, with the first case of pneumonia with no known cause. As of March 7, 2020, WHO data identified 90,870 confirmed cases with a total death of 3,112 people. As of July 22, 2020, WHO has reported 14,971,036 confirmed cases with 618,017 deaths worldwide (case fatality rate/CFR 4.1%).

Purpose. This study aims to know the characteristics of clinical symptoms in pregnancy with Coronavirus Disease (COVID-19) at RSPAD Gatot Soebroto from March 2020 to February 2021.

Method. The research design used was descriptive-analytic using a cross-sectional retrospective time approach. The research was conducted at the Fetomaternal room at RSPAD Gatot Soebroto Jakarta from March 2020 to February 2021. The instrument used was data from medical records. The variables used were age, parity, gestational age, comorbidities of pregnancy, and the severity of COVID-19.

Results. The age of most pregnant women was between the age of 24 years in six people (8%), age 28 years in eight people (10.7%), age 30 years in eight people (10.7%), age 34 years in six people (8%), and age 39 years in six people (8%), with a minimum age of 21 years and a maximum age of 42 years, from 75 pregnant women with COVID-19. Pregnant women with COVID-19 age at risk were 15 people (20%), and pregnant women with COVID-19 at no risk age were 60 people (80%). In addition, 59 people had multigravida (78.7%), while primigravida was in 16 people (21.3%). The term gestational age was present in 72 mothers (96.0%), and a small proportion of preterm gestational age was present in three mothers (4%). Among pregnant women with COVID-19, on average, they had no comorbidities, and the most common comorbidities of pregnancy were PEB in eight women (10.7), HBsAg (+) in three women (4%), and asthma in two women (2.7%). Furthermore, the majority of the severity of COVID-19 in pregnant women was mild in 63 women (84.0%) and severe only in three women (4%).

Conclusion. The study results through the literature review showed that pregnant women aged 28 and 30 years were the most age of pregnant women, namely 10.7%. Most of the pregnant women were multigravida with 78.7%. In addition, 96.0% of pregnant women were at term gestational age. Then, the most comorbidities of pregnant women were pre-eclampsia at 10.7%. Meanwhile, the 84% majority severity of COVID-19 in pregnant women was at mild levels.

Suggestions: Most COVID-19 levels in pregnant women were mild at 63 mothers (84.0%) and severe only in three mothers (4%). Thus, it is recommended to self-isolate. For returning patients, when pregnant women are declared to self-isolate, the hospital arranges procedures for the discharge of pregnant patients with COVID-19 who can transmit, even with mild symptoms.

 

Keywords: Age, COVID-19, pregnancy comorbidities, gestational age, pregnant women, parity, the severity of COVID-19.

 

  1. Chen, et al. 2020. Clinical Characteristics of pregnant women with Covid-19 in Wuhan, China. NEJM. 382 dr. Khomainy Alamsyah, Sp.OG Gejala COVID-19 pada Ibu Hamil dan Pengaruhnya pada Janin https://herminahospitals.com/id/articles/gejala-covid-19-pada-ibu-hamil-dan-pengaruhnya-pada-janin.html . 30 Juli 2021
  2. Yuliana, L. W. (2020). Karakteristik gejala klinis kehamilan dengan Coronavirus disease (COVID-19). Jurnal Ilmiah Kesehatan Sandi Husada, 9(2), 726-734.
  3. Arentz M, Yim E, Klaff L, et al. 2020. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state. JAMA. 3 23(16):1612-1614.
  4. British Medical Journal. 2020. Coronavirus disease 2019 (COVID-19). United Kingdom: 734
  5. Cao, et al. 2020. Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study. / International Journal of Infectious Diseases. 95:294-300
  6. Frazier K.M., et al. 2020. SARS-CoV-2 virus isolated from the mastoid and middle ear: implications for COVID-19 precautions during ear surgery. JAMA Otolaryngol Head Neck Surg. 1-2.
  7. Gao, et al. 2020. Clinical features and outcomes of pregnant women with COVID-19: a systematic review and meta-analysis. BMC Infectious Diseases. 20:564
  8. Handayani, et al. 2020. Penyakit virus corona 2019.J Respir Indo. 40(2):119-127.
  9. Hanun dkk. 2021. Metode penelitian kesehatan. Aceh. Yayasan penerbit Muhammad Zaini
  10. Juusela A, Nazir M, Gimovsky M. 2020. Two cases of coronavirus 2019-related cardiomyopathy in pregnancy. Am J Obstet Gynecol MFM.
  11. Kementrian Kesehatan RI. 2020. Pedoman pencegahan dan pengendalian coronavirus disease (COVID-19). Jakarta: Kemenkes RI dan Direktorat Jenderal Pencegahan dan Pengendalian Penyakit (P2P)
  12. Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. 2020. Clinical and CT imaging features of the
  13. COVID-19 pneumonia: Focus on pregnant women and children. J Infect. 80(5):7-13.
  14. Lopez, et al. 2020. Coronavirus Disease 2019 in Pregnancy: A clinical management protocol
  15. and considerations for practice. Fetal Diagn Ther. (47):519–528.
  16. Mackenzie, J.S., David W.S. 2020. COVID-19: a novel zoonotic disease caused by a coronavirus from China: what we know and what we don’t. MICROBIOLOGY AUSTRALIA
  17. Marzuki, I., Bachtiar, E., Zuhriyatun, F., Purba, A. M. V., Kurniasih, H., Purba, D. H., ... & Airlangga, E. (2021). COVID-19: seribu satu wajah. Yayasan Kita Menulis.
  18. Mentri dalam Negri. 2020. “Pedoman Umum Kesiapsiagaan Menghadapi Penyakit Coronavirus (2019-nCoV) untuk Pemerintah Daerah. Jakarta
  19. Qiancheng, et al. 2020. Coronavirus disease 2019 in pregnancy. International Journal of Infectious Diseases. 95:376-383.
  20. Ryan et al. 2020. Clinical update on COVID-19 in pregnancy: A review article. J. Obstet. Gynaecol. (46)8: 1235–1245
  21. Sairah. B., Baloch, M. A., T. Z., & X. P. 2020. The Coronavirus Disease 2019 (COVID-19)
  22. Pandemic. Tohoku J. Exp. Med. 250(4), 271-278. Sousa, et al. 2020. Effects of COVID-19 infection during pregnancy and neonatal prognosis: what Is the evidence? Int. J. Environ. Res. Public Health. 17(11):4176
  23. World Health Organization (WHO). 2020. Coronavirus disease 2019 (COVID-19) Situation Report -10. Geneva: WHO
  24. World Health Organization (WHO). 2020. Clinical Management of COVID -19; Integrim Guidance. Geneva: WHO
  25. World Health Organization (WHO). 2020. Global COVID-19 Clinical Platform with pregnancy module. Geneva: WHO
  26. Wu X, Sun R, Chen J, Xie Y, Zhang S, Wang X. 2020. Radiological findings and clinical characteristics of pregnant women with COVID-19 pneumonia. Int J Gynaecol Obstet. (150):58–63
  27. Yu, et al. 2020. Clinical features and obstetric and neonatal outcomes of pregnant patients
  28. with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. The Lancet Infectious Disease. 20(5):559-564
  29. Zeng, et al. 2020. A comparison study of SARS‐CoV‐2 IgG antibody between male and female COVID‐19 patients: A possible reason underlying different outcome between sex. J Med Virol. 1-5

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