Abstract #1184564: A 59-year-old man with type 2 diabetes mellitus with severe neuropsychiatric manifestations due to COVID-19 infection
Introduction
Hyperglycemia in diabetes patients is associated with an increased risk for neuropsychiatric complications. SARS-CoV-2, COVID-19 is a serious pathogen with further exacerbation of neurological manifestations in patients with diabetes with a high risk for morbidity and mortality.
Section snippets
Case Description
We present a case of a 59-year-old man with poorly controlled type 2 diabetes (T2DM) for 16 years, dyslipidemia, and hypertension. His recent hemoglobin A1c is 7.9%. Past psychiatric history includes well-controlled anxiety and depression. He suddenly developed lethargy, excessive sleepiness, forgetfulness, confusion, and altered behavior. He tested positive for COVID-19 despite having received two doses of the vaccine a few months earlier but he did not develop respiratory symptoms. Magnetic
Discussion
A literature review revealed variable presentation of neurological manifestations in patients with COVID-19 infection. T2DM patients have higher rates of anxiety and depression scores as well as a higher risk of developing Parkinson’s disease and Alzheimer’s dementia as compared to non-diabetic individuals.
Studies suggest that in T2DM patients with long-term hyperglycemia, the coronavirus binds to angiotensin-converting enzyme -2 (ACE2) receptors which may exacerbate the development of