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Abstract

Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8–99.3%) using a penalised logistic regression model.

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/content/10.2807/1560-7917.ES.2021.26.5.2100092
2021-02-04
2024-04-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.5.2100092
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References

  1. Jeffery-Smith A, Dun-Campbell K, Janarthanan R, Fok J, Crawley-Boevey E, Vusirikala A, et al. Infection and transmission of SARS-CoV-2 in care homes reporting no cases or outbreaks of COVID-19 in England: a prospective observational cohort study. Lancet Reg Heal Eur. 2021. Epub ahead of print.  https://doi.org/10.1016/j.lanepe.2021.100038 
  2. Ladhani SN, Jeffery-Smith A, Patel M, Janarthanan R, Fok J, Crawley-Boevey E, et al. High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19: Prospective cohort study, England. EClinicalMedicine. 2020;28:100597.  https://doi.org/10.1016/j.eclinm.2020.100597 
  3. Ladhani SN, Chow JY, Janarthanan R, Fok J, Crawley-Boevey E, Vusirikala A, et al. Investigation of SARS-CoV-2 outbreaks in six care homes in London, April 2020. EClinicalMedicine. 2020;26(0):100533. PMID: 32923993 
  4. Harvala H, Mehew J, Robb ML, Ijaz S, Dicks S, Patel M, et al. Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020. Euro Surveill. 2020;25(28):2001260.  https://doi.org/10.2807/1560-7917.ES.2020.25.28.2001260  PMID: 32700670 
  5. UK Government. NHS. Care Home COVID-19 Testing Guidance. For testing of staff and residents. London: UK Government. NHS. Jan 2021. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/957849/Care_Home_Testing_Guidance_England_v21-01.pdf
  6. McMichael TM, Currie DW, Clark S, Pogosjans S, Kay M, Schwartz NG, et al. Epidemiology of covid-19 in a long-term care facility in King County, Washington. N Engl J Med. 2020;382(21):2005-11.  https://doi.org/10.1056/NEJMoa2005412  PMID: 32220208 
  7. Patel MC, Chaisson LH, Borgetti S, Burdsall D, Chugh RK, Hoff CR, et al. Asymptomatic SARS-CoV-2 Infection and COVID-19 Mortality During an Outbreak Investigation in a Skilled Nursing Facility. Clin Infect Dis. 2020;71(11):2920-6.  https://doi.org/10.1093/cid/ciaa763  PMID: 32548628 
  8. Wajnberg A, Mansour M, Leven E, Bouvier NM, Patel G, Firpo-Betancourt A, et al. Humoral response and PCR positivity in patients with COVID-19 in the New York City region, USA: an observational study. Lancet Microbe. 2020;1(7):e283-9.  https://doi.org/10.1016/S2666-5247(20)30120-8  PMID: 33015652 
  9. Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Spijker R, Taylor-Phillips S, et al. Antibody tests for identification of current and past infection with SARS-CoV-2. Cochrane Database Syst Rev. 2020;6(6):CD013652.  https://doi.org/10.1002/14651858.CD013652  PMID: 32584464 
  10. Graham NSN, Junghans C, McLaren R, Randell P, Lang N, Ladhani SN, et al. High rates of SARS-CoV-2 seropositivity in nursing home residents. J Infect. S0163-4453(20)30574-0. 27 Aug. 2020,  https://doi.org/10.1016/j.jinf.2020.08.040 
  11. Ladhani SN, Chow JY, Atkin S, Brown KE, Ramsay ME, Randell P, et al. Regular mass screening for SARS-CoV-2 infection in care homes already affected by COVID-19 outbreaks: Implications of false positive test results. J Infect. 2020;0(0):4840.  https://doi.org/10.1016/j.jinf.2020.09.008  PMID: 32949618 
  12. Addetia A, Crawford KHD, Dingens A, Zhu H, Roychoudhury P, Huang ML, et al. Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate. J Clin Microbiol. 2020;58(11):e02107-20.  https://doi.org/10.1128/JCM.02107-20  PMID: 32826322 
  13. Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020;369(6505):806-11.  https://doi.org/10.1126/science.abc6284  PMID: 32434945 
  14. Lumley SF, O'Donnell D, Stoesser NE, Matthews PC, Howarth A, Hatch SB, et al. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. N Engl J Med. 2020 Dec 23:NEJMoa2034545.  https://doi.org/10.1056/NEJMoa2034545 . Epub ahead of print. PMID: 33369366; PMCID: PMC7781098.
  15. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, et al. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell. 2020;182(4):812-827.e19.  https://doi.org/10.1016/j.cell.2020.06.043  PMID: 32697968 
Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Anna+Jeffery-Smith&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jeffery-Smith Anna</a>, <a href="/search?value1=Nalini+Iyanger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Iyanger Nalini</a>, <a href="/search?value1=Sarah+V+Williams&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Williams Sarah V</a>, <a href="/search?value1=J+Yimmy+Chow&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chow J Yimmy</a>, <a href="/search?value1=Felicity+Aiano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aiano Felicity</a>, <a href="/search?value1=Katja+Hoschler&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoschler Katja</a>, <a href="/search?value1=Angie+Lackenby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lackenby Angie</a>, <a href="/search?value1=Joanna+Ellis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellis Joanna</a>, <a href="/search?value1=Steven+Platt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Platt Steven</a>, <a href="/search?value1=Shahjahan+Miah&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miah Shahjahan</a>, <a href="/search?value1=Kevin+Brown&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brown Kevin</a>, <a href="/search?value1=Gayatri+Amirthalingam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amirthalingam Gayatri</a>, <a href="/search?value1=Monika+Patel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Patel Monika</a>, <a href="/search?value1=Mary+E+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Mary E</a>, <a href="/search?value1=Robin+Gopal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gopal Robin</a>, <a href="/search?value1=Andre+Charlett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charlett Andre</a>, <a href="/search?value1=Shamez+N+Ladhani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ladhani Shamez N</a>, <a href="/search?value1=Maria+Zambon&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zambon Maria</a></span>. Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(5):pii=2100092. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.5.2100092</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Jan 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 04 Feb 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.5.2100092
/content/10.2807/1560-7917.ES.2021.26.5.2100092
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