The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis

Authors

  • Yousef Moradi
  • Marzieh Soheili Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Hojat Dehghanbanadaki Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Ghobad Moradi Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Farhad Moradpour Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Seyede Maryam Mahdavi Mortazavi Pediatric Gastroenterology Fellowship, Department of Pediatrics, School of Medicine, Namazi teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Hamed Gilzad Kohan Western New England UniversityCollege of PharmacyDepartment of Pharmaceutical and Administrative Sciences
  • Mostafa Zareie Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

DOI:

https://doi.org/10.18433/jpps32831

Abstract

Purpose: Patients with HIV may be more likely to become severely ill from COVID-19. The present meta-analysis aims to determine the impact of HIV/AIDS infection on the clinical outcomes of COVID-19. Methods: A comprehensive literature search was performed to identify relevant cohort studies to evaluate the association of HIV/AIDS infection with clinical outcomes of COVID-19. International databases, including PubMed (Medline), Web of Sciences, Scopus, and Embase, were searched from the emergence of the COVID-19 pandemic until January 2022. We utilized the risk ratio (RR) with its 95% confidence interval (95% CI) to quantify the effect of cohort studies. Results: Twelve cohort studies were included in this meta-analysis, which examined a total number of 17,786,384 patients. Among them, 40,386 were identified to be HIV positive, and 17,745,998 were HIV negative. The pooled analyses showed HIV positive patients who were co-infected with SARS-CoV-2 were 58% more likely to develop a fever (RR=1.58; 95% CI: 1.42, 1.75), 24% more likely to have dyspnea (RR=1.24; 95% CI: 1.08, 1.41), 45% more likely to be admitted to ICU (RR=1.45; 95% CI: 1.26, 1.67), and 37% more likely to die from to COVID-19 (RR=1.37; 95% CI: 1.30, 1.45) than HIV negative patients. Conclusion: HIV/AIDS coinfection with COVID 19 increased the risk of fever, dyspnea, ICU admission, and mortality.

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Author Biography

Hamed Gilzad Kohan, Western New England UniversityCollege of PharmacyDepartment of Pharmaceutical and Administrative Sciences

Department of Pharmaceutical and Administrative Sciences

Associate Professor

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Published

2022-06-01

How to Cite

Moradi, Y. ., Soheili, M. ., Dehghanbanadaki, H. ., Moradi, G. ., Moradpour, F. ., Mahdavi Mortazavi, S. M. ., … Zareie, M. . (2022). The Effect of HIV/AIDS Infection on the Clinical Outcomes of COVID-19: A Meta-Analysis. Journal of Pharmacy & Pharmaceutical Sciences, 25, 183–192. https://doi.org/10.18433/jpps32831

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Section

Systematic Review and Meta-Analysis