Combination of the therapy of the anticoagulants and Tivortin in patients with cardiac ishemia at COVID-19

  • M.J. Dzhumaeva State Institution “Republican Clinical Center of Cardiology”, Dushanbe, Tajikistan
  • A.I. Tabarov State Institution “Republican Clinical Center of Cardiology”, Dushanbe, Tajikistan
  • Kh.T. Fayzulloev State Institution “Republican Clinical Center of Cardiology”, Dushanbe, Tajikistan

Abstract

Background. Аn L-arginine is a conditionally essential amino acid. The daily average requirement is 4.2 mg. The L-arginine exhibits angioprotective properties, regulates proliferation and apoptosis, oxidative processes, blocks platelet aggregation and has a fibrinolytic effect ‒ antithrombotic (prevents the adhesion of circulating platelets and leukocytes) for anti-inflammatory effects. The likelihood of developing thrombotic complications in all patients with COVID-19 is very high, such patients are recommended to double dosage of anticoagulants.

Objective. To study the combination of the anticoagulant therapy and the drug Tivortin in patients with coronary artery disease with COVID-19.

Materials and methods. 28 patients with the cardiac ischemia of the exertion stenocardia functional class II-III with COVID-19 were examined. The patients were divided into the main and control groups. One of the groups, in addition to the anticoagulant therapy Clexan 2 times 0.6 mg, have taken the drug Tivortin, manufactured by “Yuria-Pharm” (Ukraine), containing L-arginine (4.2 mg).

Results. The therapy with the use of the nitrate oxide donors in combination with the anticoagulants in the main group showed an increase in exercise tolerance, in the SpO2 level, i.e., a decrease in hypoxia in the main group compared with the control group.

Conclusions. The addition of Tivortin to the therapy of anticoagulants that inhibit the activity of the blood coagulation system may increase the chances of survival of patients hospitalized with COVID-19.

Keywords: ischemic heart disease, therapy.
Published
2020-10-21
How to Cite
Dzhumaeva, M., Tabarov, A., & Fayzulloev, K. (2020). Combination of the therapy of the anticoagulants and Tivortin in patients with cardiac ishemia at COVID-19. Infusion & Chemotherapy, (3.1), 91-91. https://doi.org/10.32902/2663-0338-2020-3.1-76
Section
Materials of IV International Congress of infusion therapy