A commentary on

Eghbali Zarch R, Hosseinzadeh P.

COVID-19 from the perspective of dentists: A case report and brief review of more than 170 cases. Dermatol Ther 2021; DOI: 10.1111/dth.14717.

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GRADE rating

Commentary

The World Health Organisation declared COVID-19 a pandemic on 11 March 2020. Since then, this disease has caused a significant number of deaths in many countries worldwide. The disease is caused by one of the coronaviruses (SARS-CoV-2) which is a contagious respiratory virus. The initial symptoms to be aware of include fever, a new continuous cough and a loss or change in the sense of smell or taste as highlighted by the NHS inform website.1

This systematic review suggests that there are a range of oral manifestations that can occur as a result of COVID-19, ranging from dry mouth to opportunistic infections such as Candida albicans. It was highlighted that in some cases, oral symptoms may be the initial or only sign of the disease, and as healthcare professionals, a careful clinical oral examination should be carried out with this in mind.

There are a few issues in the systematic review that could have been avoided to improve its quality: 1) the search was limited to two databases; 2) it was not clear whether the risk of bias assessment was addressed, as it did not allude to how disagreements were addressed; and 3) due to the presence of some missing data across all of the studies included, it is difficult to quantitatively analyse and compare oral manifestations and disease patterns (as acknowledged by the authors).

Furthermore, papers were retrieved from an electronic database search only, while grey literature was not searched or included. Only English language studies were included, meaning studies in different languages which could have some potential relevance may have been missed, particularly considering that this is a worldwide pandemic.

When considering risk of bias, it was not disclosed whether or not a tool was used in order to assess the quality or accuracy of the studies included. With COVID-19 being a new condition, the number of studies concerned with oral manifestations are limited and more research is required in this field. The final conclusion is too vague to suggest that we should implement changes to our practice. The outbreak of COVID-19 has caused delays in carrying out oral examinations and oral manifestations may be misdiagnosed or there may be coincidental findings; therefore, more research is required into this topic.