The Informative Nature of the Disappeared SARS-CoV-2 Genomic Sequences: A Mini-review with Perspectives

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its mortal coronavirus disease 2019 (COVID-19) are still mysterious in nature. The emergence of the more virulent newer SARS-CoV-2 variants, e.g., Delta and Omicron variants, made the matters worse. CoViTris2020 compound can be considered the most potent investigational anti-COVID-19 agent among others to date. Meanwhile, all countries took very serious steps in vaccination and have started to vaccinate their citizens beginning with the elders. The current data refer that, in the near future, the available vaccines may gradually lose their effectiveness against the newer SARS-CoV-2 strains which have increased transmissibility and infectivity due to the enhanced human angiotensin-converting enzyme 2 (hACE2) affinities and antibodies resistances, respectively. All the problems facing the continuous and successful use of the current vaccines, antiviral agents, and convalescent plasma in their missions against the COVID-19 infection force us to deeply investigate all the updated available data about all the components of the pandemic in a comprehensive way hour by hour to reveal all the secrets and clues behind the SARS-CoV-2. Herein, a brief article about the up-to-date clues, hypotheses, facts, unsolved issues, and informative genetic data of SARS-CoV-2/COVID-19 is introduced.