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Value of Thiol and Ischemia Modified Albumin (IMA) in Predicting Mortality in Serious COVID-19 Pneumonia

19 Pages Posted: 27 Sep 2022 Publication Status: Published

See all articles by Tarık Acar

Tarık Acar

University of Health Sciences Turkey - Beyhekim Training and Research Hospital

Birsen Ertekin

University of Health Sciences Turkey - Beyhekim Training and Research Hospital

Mehmet Yortanlı

Numune State Hospital

Abstract

Background/aim: This study was determined the serum levels of thiol and ischemia-modified albumin (IMA) in patients with severe COVID-19 pneumonia to evaluate oxidative stress.

Methods: A total of 153 patients who had been confirmed with severe COVID-19 pneumonia in the emergency unit were prospectively analyzed. The control group was formed by 50 healthy volunteers with similar age and no chronic disease history. Thiol and IMA levels were statistically compared both in the patient and the control groups, and within the patient groups (survived and died).

Results: While 96 out of 153 patients had survived, 57 patients had died. There was a statistically significant distinction between the survived and died patients with regard to Thiol and IMA levels (p<0.001). Thiol level was significantly lower and IMA level was significantly higher in the patient group to comparate control group (p<0.001). The sensitivity, specificity and NPV were 70.2%, 86.5% and 83% when thiol cut-off value was ≤ 345.2 µmol/L (AUC: 0.886, p<0.001). The sensitivity, specificity and NPV were 70.2%, 85.4% and 82.8% when the IMA cut-off was > 302.9 ABSU (AUC: 0.875, p<0.001).

Conclusions: Our results demonstrate that thiol and IMA levels may be used as bioindicators for diagnosis, risk classification and mortality in patients with serious COVID-19 pneumonia.

Funding Information: None.

Declaration of Interests: No authors declared any potential conflict of interest

Ethics Approval Statement: The study was approved by the Local Ethics Committee of Necmettin Erbakan University Faculty of Medicine [date: 03/09/2021 and number: 2021/3326 (6903)]. We declare that this study is compatible with the ethical standards of Helsinki Declaration. Prior to the study, all patients and volunteers were informed about the study and written consents were obtained.

Keywords: thiol, ischemia-modified albumin, covıd-19, prognosıs, mortality

Suggested Citation

Acar, Tarık and Ertekin, Birsen and Yortanlı, Mehmet, Value of Thiol and Ischemia Modified Albumin (IMA) in Predicting Mortality in Serious COVID-19 Pneumonia. Available at SSRN: https://ssrn.com/abstract=4214233 or http://dx.doi.org/10.2139/ssrn.4214233

Tarık Acar (Contact Author)

University of Health Sciences Turkey - Beyhekim Training and Research Hospital ( email )

Birsen Ertekin

University of Health Sciences Turkey - Beyhekim Training and Research Hospital ( email )

Mehmet Yortanlı

Numune State Hospital ( email )

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