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  • POS1251 INCIDENCE AND OUTCOMES OF SARS-CoV-2 INFECTION IN PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES: A POPULATION-BASED STUDY OF MORE THAN FOUR MILLION INHABITANTS IN THE LAZIO ITALIAN REGION

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Scientific Abstracts
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COVID-19
POS1251 INCIDENCE AND OUTCOMES OF SARS-CoV-2 INFECTION IN PATIENTS WITH SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES: A POPULATION-BASED STUDY OF MORE THAN FOUR MILLION INHABITANTS IN THE LAZIO ITALIAN REGION
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  1. E. De Lorenzis1,2,3,
  2. P. Parente4,
  3. G. Natalello1,
  4. S. Soldati2,
  5. S. L. Bosello1,
  6. A. Barbara4,
  7. C. Sorge2,
  8. S. Axelrod5,
  9. L. Verardi1,
  10. P. G. Cerasuolo1,
  11. G. Peluso1,
  12. A. Gemma2,
  13. M. Davoli2,
  14. D. Biliotti2,
  15. V. Bruzzese4,6,
  16. M. Goletti4,
  17. M. DI Martino2,
  18. M. A. D’agostino1
  1. 1Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, Roma, Italy, Rheumatology Department, Roma, Italy
  2. 2Local Public Health Office Roma 1, Department of Epidemiology, Roma, Italy
  3. 3University of Verona-Verona, Italy, Ph.D. Programme in Biomolecular Medicine-Cycle XXXV, Verona, Italy
  4. 4Local Public Health Office Roma 1, Health Directorate, Roma, Italy
  5. 5University of Sechenov, Institute of Leadership, Moscow, Russian Federation
  6. 6Nuovo Regina Margherita Hospital, Department of Internal Medicine, Rheumatology and Gastroenterology, Roma, Italy

Abstract

Background The impact of the severe acute respiratory syndrome Coronavirus 2 disease (COVID-19) pandemic on people with systemic autoimmune rheumatic diseases (SARDs) remains to be fully established. It is unclear whether SARDs are an independent risk factor for COVID-19 infection and poor outcome.

Objectives The aim of our study is to assess the incidence and prognosis of test-proven SARS-CoV-2 infection during the first COVID-19 wave in a large population of SARD patients of the Lazio Italian region.

Methods We retrospectively evaluated in a cohort of 4.716.119 subjects aged over 18 years and affiliated to the health system of the Lazio Italian Region, the incidence and 30-day outcomes of COVID-19 infection in 40.490 SARD pts and compared to the affiliated population as incidence rate ratio adjusted for demographics and comorbidities (adjIRR). SARD diagnosis and comorbidities were derived from medical administrative records using the Chronic Related Group classification system. Data on COVID-19 infection were derived from a dedicated regional digital network.

Results The risk of COVID-19 infection was increased in patients with Psoriatic Arthritis (adjIRR=1.21, 95% CI 1.10-1.33) and Undifferentiated Connective Tissue Disease (adjIRR=1.26, 95% CI 1.03-1.54). The risk of hospitalisation was higher in patients with Axial Spondylarthritis (adjIRR=2.16, 95% CI 1.45-3.22), and Systemic Vasculitis (adjIRR=1.81, 95% CI 1.07-3.06) while the risk of Intensive care unit admission was higher in Systemic Erythematous Lupus (adjIRR=3.67, 95% CI 1.52-8.83) and primary Sjögren Syndrome (adjIRR=4.13, 95% CI 1.71-9.96) patients. An increased COVID-19 mortality was reported in patients with Rheumatoid Arthritis (adjIRR=1.50, 95% CI 1.04-2.17), Systemic Erythematous Lupus (adjIRR=2.67, 95% CI 1.10-6.44), primary Sjögren Syndrome (adjIRR=2.51, 95% CI 1.12-5.62), and Scleroderma (adjIRR=4.60, 95% CI 2.06-10.29).

Conclusion The incidence of severe COVID-19 is not increased in the same percentage in SARDs. Each SARD presents a peculiar pattern in terms of increased risk of COVID-19 incidence, hospitalisation, intensive care unit admission and death, that is not linked to the immunosuppressive behaviour of the disease.

Disclosure of Interests None declared

https://doi.org/10.1136/annrheumdis-2022-eular.3587

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