ReviewAn update review of emerging small-molecule therapeutic options for COVID-19
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open access
Graphical abstract
Abbreviations
3CLpro
3C-Like protease
6MP
6-Mercaptopurine
6TG
6-Thioguanine
ACE2
Angiotensin-converting enzyme 2
AMPK
AMP-activated protein kinase
BECN1
Beclin1
BSAs
Broad-spectrum antiviral drugs
CoV
Coronavirus
COVID-19
2019 Coronavirus disease
CQ
Chloroquine
CMK
Decanoyl-RVKR-chloromethylketone
CPE
Cytopathic effect
DAAs
Direct-acting antiviral agents
DHO
Dihydroorotate
DHODH
Dihydroorotate dehydrogenase
E
Envelope protein
EBOV
Ebola virus
ELs
Endolysosomes
EUA
Emergency use authorization
FDA
US Food and Drug Administration
GM1
Monosialotetrahexosylganglioside 1
GTP
Guanosine triphosphate
HA
Haemagglutinin
HC
QHydroxychloroquine
HIV
Human immunodeficiency virus
HTAs
Host-targeting antivirals
HyCoSuL
Hybrid Combinatorial Substrate Library
IMPDH
Inosine monophosphate dehydrogenase
IFN
Interferon
IRF3
Interferon regulatory factor 3
LPV/r
Lopinavir/ritonavir
M
Membrane protein
MERS-CoV
Middle East respiratory syndrome coronavirus
Mpro
Main protease
N
Nucleocapsid protein
NIAID
National Institute of Allergy and Infectious Diseases
nsps
Non-structural proteins
PC
Pro-protein convertase
PIP2
Phosphatidylinositol 4,5-bisphosphate
PLpro
Papain-like protease
PP2A
Protein phosphatase 2A
RBV
Ribavirin
RDP
Ribavirin diphosphate
RdRp
RNA-dependent RNA polymerase
RMP
Ribavirin monophosphate
RTP
Ribavirin triphosphate
S
Spike protein
SAR
Structure-activity relationship
SARS-CoV
Severe acute respiratory syndrome coronavirus
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
SKP2
S-Phase kinase-associated protein 2
TGN
Trans-Golgi network
WHO
World Health Organization
Keywords
Coronaviruses
SARS-CoV-2
RNA-dependent RNA polymerase (RdRp)
3C-like protease (3CLpro)
Papain-like protease (PLpro)
Transmembrane serine protease (TMPRSS2)
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© 2021 The Author(s). Published by Elsevier Masson SAS.