Elsevier

Journal of Neuroimmunology

Volume 360, 15 November 2021, 577704
Journal of Neuroimmunology

Short Communication
Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report

https://doi.org/10.1016/j.jneuroim.2021.577704Get rights and content

Highlights

  • COVID-19 can cause Multisystem Inflammatory Syndrome in Children in association with transverse myelitis

  • Transverse myelitis associated with COVID-19 can involve both grey and white matter at multiple levels

  • Infliximab can may be considered as a treatment option in Pediatric COVID-19 patients presenting with signs and symptoms of transverse myelitis.

Abstract

COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis.

Keywords

COVID-19
Multi-System Inflammatory Syndrome
Transverse myelitis
Pediatric
Infliximab
Immunotherapy

Abbreviation

SARS-CoV-2
Severe acute respiratory syndrome coronavirus-2
COVID-19
Coronavirus disease 2019
Multi-System Inflammatory Syndrome in Children
MIS-C
TM
Transverse myelitis
LETM
longitudinally extensive transverse myelitis
IVIG
intravenous immunoglobulin
CMV
cytomegalovirus
TNF-α
tumor necrosis factor alpha

Cited by (0)

1

AS and ZP have contributed equally to this article.

View Abstract