Elsevier

Medical Hypotheses

Volume 144, November 2020, 109976
Medical Hypotheses

Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy

https://doi.org/10.1016/j.mehy.2020.109976Get rights and content

Abstract

Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 from prepone targets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificial surfactant system as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2.

Keywords

SARS-CoV-2
COVID-19
Coronavirus
ACE2 receptors
Pulmonary surfactant
Molecular tropism
ARDS

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