Clinical Effect of Q192R Paraoxonase 1 Polymorphism and its Related Variables on the COVID-19 Intensity Considering Gender and Post-COVID Complications

20 Pages Posted: 11 Apr 2022

See all articles by Zohreh-al-sadat Ghoreshi

Zohreh-al-sadat Ghoreshi

Kerman University of Medical Sciences

Mojtaba abasi

Kerman University of Medical Sciences

Gholamreza Asadikaram

Kerman University of Medical Sciences - Afzalipour School of Medicine

Mohsen sharif-zak

Kerman University of Medical Sciences

Mitra Rezazadeh-Jabalbarzi

Jiroft University of Medical Sciences

Hamidreza rashidinejad

Jiroft University of Medical Sciences

Mohammadreza Zangouey

Kerman University of Medical Sciences

Abstract

Objective: In this study, we aimed to investigate the effect of rs662 polymorphism of paraoxonase 1 (PON1), PON1 arylesterase (ARE) activity, and the serum lipid profile in patients with COVID-19 in different stages of the disease considering post-COVID outcomes.

Methods: 470 COVID-19 patients (235 females and 235 males) were recruited into the study, and based on the World Health Organization (WHO) criteria, the patients were divided into three groups: moderate, severe, and critical. rs662 PON1 polymorphism was determined by the Alw 1 enzyme followed by agarose gel electrophoresis. Moreover, serum levels of triglycerides (TG), cholesterol (Chol), high-density lipoprotein-cholesterol (HDL-c), and low-density lipoprotein-cholesterol (LDL-c), as well as the level of the ARE activity of PON1 in the serum of patients, were measured at the time of infection and one and three months after hospitalization.

Results: There was a significant relationship between the G allele and the severity of the disease. In addition, the probability of death in homozygous individuals (GG) was higher than in heterozygous patients (GA) and it was higher in heterozygous patients than in wild-type individuals (AA). There was also a significant relationship between the decrease in serum lipids and the intensity of COVID-19. On the other hand, at the onset of the disease, the HDL-c level, and serum ARE activity were reduced compared to one and three months after COVID-19 infection.

Conclusion: The findings of this study indicated the significant impact of rs662 polymorphism on ARE activity, lipid profiles, disease severity, and mortality in COVID-19 patients.

Note:
Funding Information: The present study was extracted from the PHD thesis of Zohreh-al-sadat Ghoreshi, which was funded by Kerman University of Medical Sciences (Tracking Code: 400000242).

Conflict of Interests: None.

Ethical Approval: The project was approved by ethic committee of Kerman University Medical Sciences (Ethics code: IR.KMU.REC.1400.412).

Keywords: COVID-19, PON1, rs662, Serum lipids, ARE activity

Suggested Citation

Ghoreshi, Zohreh-al-sadat and abasi, Mojtaba and Asadikaram, Gholamreza and sharif-zak, Mohsen and Rezazadeh-Jabalbarzi, Mitra and rashidinejad, Hamidreza and Zangouey, Mohammadreza, Clinical Effect of Q192R Paraoxonase 1 Polymorphism and its Related Variables on the COVID-19 Intensity Considering Gender and Post-COVID Complications. Available at SSRN: https://ssrn.com/abstract=4051104 or http://dx.doi.org/10.2139/ssrn.4051104

Zohreh-al-sadat Ghoreshi

Kerman University of Medical Sciences ( email )

Kerman
Iran

Mojtaba Abasi

Kerman University of Medical Sciences ( email )

Kerman
Iran

Gholamreza Asadikaram (Contact Author)

Kerman University of Medical Sciences - Afzalipour School of Medicine ( email )

Kerman
Iran

Mohsen Sharif-zak

Kerman University of Medical Sciences ( email )

Kerman
Iran

Mitra Rezazadeh-Jabalbarzi

Jiroft University of Medical Sciences ( email )

Jiroft
Iran

Hamidreza Rashidinejad

Jiroft University of Medical Sciences ( email )

Jiroft
Iran

Mohammadreza Zangouey

Kerman University of Medical Sciences ( email )

Kerman
Iran

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