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Case report
Novel case of takotsubo cardiomyopathy following COVID-19 vaccination
  1. Caitlin Stewart1,
  2. David T Gamble1,2 and
  3. Dana Dawson1,2
  1. 1Cardiology and Cardiovascular Research Unit, University of Aberdeen, Aberdeen, UK
  2. 2Cardiology Department, NHS Grampian, Aberdeen, UK
  1. Correspondence to Dr David T Gamble; david.gamble1{at}nhs.scot

Abstract

We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management was commenced. Further investigations revealed non-obstructive coronary arteries on coronary angiography and imaging revealed hypokinesia of the anterior and anterior-septal walls in the apex and midcavity level, myocardial oedema and no infarction, all in keeping with TTC. Given the large-scale roll out of vaccinations during the COVID-19 pandemic better understanding of potential adverse events is essential. This is the first case report of TTC following a second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination.

  • cardiovascular medicine
  • COVID-19
  • healthcare improvement and patient safety

This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

https://bmj.com/coronavirus/usage

https://doi.org/10.1136/bcr-2021-247291

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    Footnotes

    • Contributors CS was involved with the preparation of the first draft of this paper and subsequent review. DG was involved in the clinical care of this patient, preparation of the images, first draft of this paper and subsequent review. DD had the idea of this case report, was involved in the clinical care of this patient, review of the first draft of this paper and subsequent review.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.