Abstract
Supporting Institution
yok
Project Number
yok
References
- Ozcelik F, Tanoglu A, Çıracı MZ, Ozcelik IK. Use of immune modulator interferon-gamma to support combating COVID-19 pandemic. Int J Coronaviruses 2020; 1: 1-15.
- World Health Organization (WHO). Coronavirus disease 2019 ( COVID-19): situation report - 61. March 20, 2020. Geneva: World Health Organization Geneva; 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200321-sitrep-61-covid-19.pdf?sfvrsn=ce5ca11c_2. Accessed in 2021 (Jun 16).
- COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University(JHU). Available from: https://coronavirus.jhu.edu/map.html.
- Jiehao C, Jin X, Daojiong L, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis 2020; 71: 1547-51.
- Liu W, Zhang Q, Chen J, et al. Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020; 382: 1370-1.
- Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395: 1054-62.
- CDC COVID-19 Response Team. Preliminary estimates of the prevalence of selected underlying health conditions among patients with Coronavirus disease 2019-United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 382–6
- Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020: e20200702.
- Bhatty SA, Shaikh NA, Irfan M, Kashif SM, Vaswani AS, Sumbhai A, Gunpat. Vitamin D deficiency in fibromyalgia. J Pak Med Assoc 2010; 60: 949-51.
- Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am 2010; 39: 287-contents.
- Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 1990; 33: 160-72.
- Altındağ O, Öğüt E, Gür A, Gürsoy S, Günay M. Serum vitamin D level and its relation with clinical parameters in fibromyalgia as a neuropathic pain. Orthop Muscular Syst 2014; 3: 171.
- Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006; 134: 1129-40.
- Schöttker B, Haug U, Schomburg L, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J. Clin Nutr 2013; 97: 782-93.
- Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003; 88: 296-307.
- Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008; 87: 1080-6.
- Sağır M, Kaplan M, Tanoğlu A, Demirel F. Relationship between vitamin D levels and mortality rates of critically ill patients in intensive care unit. Anatolian Curr Med J 2021; 3: 171-5.
- Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012; 380: 219-29.
- Okyay R, Koçyiğit B, Gürsoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Mediterr 2016; 32: 243-47.
- Masuko K. The multifaceted effects of vitamin D and its potential contribution to rheumatoid arthritis. British Journal of Medicine and Medical Research 2014; 4: 1680-90.
- Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1, 25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004; 80: 1717-20.
- Commission WMH Report of clustering pneumonia of unknown etiology in Wuhan City (2019-2020).
- Hong M, Xiong T, Huang J, et al. Association of vitamin D supplementation with respiratory tract infection in infants. Matern Child Nutr 2020; 16: e12987.
- Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol 2006; 6: 271-76.
- Ishii K, Takeuchi H, Fukunaga K, et al. Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade. Exp Lung Res 2015; 41: 199-207.
- Molloy EJ, Murphy N. Vitamin D, Covid-19 and Children. Ir Med J 2020; 113: 64.
- Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res 2020; 32: 1195-8.
- Chowdhury R, Taneja S, Bhandari N, et al. Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis. PLoS One 2017; 12: e0170509.
- Banajeh SM. Nutritional rickets and vitamin D deficiency- -association with the outcomes of childhood very severe pneumonia: a prospective cohort study. Pediatr Pulmonol 2009; 44: 1207-15.
- Yao J, Liu L, Chen G, et al. Two severe cases of H7N9 pneumonia patients with immunoneuroendocrine axis dysfunction and vitamin D insufficiency. BMC Infect Dis 2014; 28: 44.
- Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678-88.
- Arihiro S, Nakashima A, Matsuoka M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza and upper respiratory infection in patients with inflammatory bowel disease. Inflamm Bowel Dis 2019; 25: 1088-95.
- Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91: 1255-60.
- Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics 2012; 130: 561-7.
- Uçar F, Taşlıpınar MY, Soydaş AÖ, Özcan N. 25-OH vitamin D levels in patients admitted to Ankara Etlik İhtisas Training and Research Hospital. Eur J Basic Med Sci 2012; 2: 12-5.
- Erol AM, Çelik C, Hacıoğlu K, et al. The relationship between vitamin D level and lipid profile in patients admitted to Physical Medicine and Rehabilitation outpatient clinic. Ege Med J 2015; 54: 173-6.
- Silva MC, Furlanetto TW. Does serum 25-hydroxyvitamin D decrease during acute-phase response? A systematic review. Nutr Res 2015; 35 : 91-6.
- Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. Eur J Clin Nutr 2020; 74: 856-9.
Abstract
Aim: With this study, the aim was to evaluate the serum 25-hydroxy vitamin D levels in COVID-19 positive patients.
Material and Method: The study retrospectively screened the archive records for patient data from 732 patients, attending the pandemic clinic in our hospital from March 2020 to February 2021 aged over 18 years with COVID-19 positivity and serum 25-hydroxy vitamin D levels examined, with data from 360 control patients between the same dates in similar age group and without COVID-19 positivity. COVID-19 positive patients and control group patients were divided into three groups according to serum 25-hydroxy vitamin D levels (deficiency, insufficiency, and normal level).
Results: Of the 732 COVID-19 positive patients included in the study, 66.4% were female (n=486) and 33.6% were male (n=246). The mean serum 25(OH)D level in the COVID-19 positive patient group was calculated as 14.2± 11.7 ng/ml. For the 360 patients included in the COVID-19 negative control group, 70% were female (n=252) and 30% were male (n=108). Mean serum 25(OH)D level in the COVID-19 negative control group was 27.6±12.1 ng/l. There was a significant difference between the groups (p=0.012).
Conclusion: High rates of vitamin D deficiency and insufficiency are seen in COVID-19 positive patients. Sufficient levels of replacement for patients with low vitamin D levels will provide significant reductions in musculoskeletal system symptoms and complaints of patients. We think vitamin D is a protective vitamin for COVID-19.
Keywords
Project Number
yok
References
- Ozcelik F, Tanoglu A, Çıracı MZ, Ozcelik IK. Use of immune modulator interferon-gamma to support combating COVID-19 pandemic. Int J Coronaviruses 2020; 1: 1-15.
- World Health Organization (WHO). Coronavirus disease 2019 ( COVID-19): situation report - 61. March 20, 2020. Geneva: World Health Organization Geneva; 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200321-sitrep-61-covid-19.pdf?sfvrsn=ce5ca11c_2. Accessed in 2021 (Jun 16).
- COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University(JHU). Available from: https://coronavirus.jhu.edu/map.html.
- Jiehao C, Jin X, Daojiong L, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis 2020; 71: 1547-51.
- Liu W, Zhang Q, Chen J, et al. Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med 2020; 382: 1370-1.
- Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395: 1054-62.
- CDC COVID-19 Response Team. Preliminary estimates of the prevalence of selected underlying health conditions among patients with Coronavirus disease 2019-United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 382–6
- Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020: e20200702.
- Bhatty SA, Shaikh NA, Irfan M, Kashif SM, Vaswani AS, Sumbhai A, Gunpat. Vitamin D deficiency in fibromyalgia. J Pak Med Assoc 2010; 60: 949-51.
- Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am 2010; 39: 287-contents.
- Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 1990; 33: 160-72.
- Altındağ O, Öğüt E, Gür A, Gürsoy S, Günay M. Serum vitamin D level and its relation with clinical parameters in fibromyalgia as a neuropathic pain. Orthop Muscular Syst 2014; 3: 171.
- Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006; 134: 1129-40.
- Schöttker B, Haug U, Schomburg L, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J. Clin Nutr 2013; 97: 782-93.
- Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003; 88: 296-307.
- Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008; 87: 1080-6.
- Sağır M, Kaplan M, Tanoğlu A, Demirel F. Relationship between vitamin D levels and mortality rates of critically ill patients in intensive care unit. Anatolian Curr Med J 2021; 3: 171-5.
- Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 2012; 380: 219-29.
- Okyay R, Koçyiğit B, Gürsoy S. Vitamin D levels in women with fibromyalgia and relationship between pain, tender point count and disease activity. Acta Med Mediterr 2016; 32: 243-47.
- Masuko K. The multifaceted effects of vitamin D and its potential contribution to rheumatoid arthritis. British Journal of Medicine and Medical Research 2014; 4: 1680-90.
- Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1, 25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004; 80: 1717-20.
- Commission WMH Report of clustering pneumonia of unknown etiology in Wuhan City (2019-2020).
- Hong M, Xiong T, Huang J, et al. Association of vitamin D supplementation with respiratory tract infection in infants. Matern Child Nutr 2020; 16: e12987.
- Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol 2006; 6: 271-76.
- Ishii K, Takeuchi H, Fukunaga K, et al. Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade. Exp Lung Res 2015; 41: 199-207.
- Molloy EJ, Murphy N. Vitamin D, Covid-19 and Children. Ir Med J 2020; 113: 64.
- Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res 2020; 32: 1195-8.
- Chowdhury R, Taneja S, Bhandari N, et al. Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis. PLoS One 2017; 12: e0170509.
- Banajeh SM. Nutritional rickets and vitamin D deficiency- -association with the outcomes of childhood very severe pneumonia: a prospective cohort study. Pediatr Pulmonol 2009; 44: 1207-15.
- Yao J, Liu L, Chen G, et al. Two severe cases of H7N9 pneumonia patients with immunoneuroendocrine axis dysfunction and vitamin D insufficiency. BMC Infect Dis 2014; 28: 44.
- Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678-88.
- Arihiro S, Nakashima A, Matsuoka M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza and upper respiratory infection in patients with inflammatory bowel disease. Inflamm Bowel Dis 2019; 25: 1088-95.
- Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91: 1255-60.
- Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics 2012; 130: 561-7.
- Uçar F, Taşlıpınar MY, Soydaş AÖ, Özcan N. 25-OH vitamin D levels in patients admitted to Ankara Etlik İhtisas Training and Research Hospital. Eur J Basic Med Sci 2012; 2: 12-5.
- Erol AM, Çelik C, Hacıoğlu K, et al. The relationship between vitamin D level and lipid profile in patients admitted to Physical Medicine and Rehabilitation outpatient clinic. Ege Med J 2015; 54: 173-6.
- Silva MC, Furlanetto TW. Does serum 25-hydroxyvitamin D decrease during acute-phase response? A systematic review. Nutr Res 2015; 35 : 91-6.
- Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. Eur J Clin Nutr 2020; 74: 856-9.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Article |
| Authors | |
| Project Number | yok |
| Publication Date | September 24, 2021 |
| Published in Issue | Year 2021 Volume: 4 Issue: 6 |
Cited By
Vitamin D levels and in-hospital mortality of COVID-19
Journal of Health Sciences and Medicine
https://doi.org/10.32322/jhsm.1056650
Serum 25-hydroxy vitamin D, vitamin B12 and folic acid levels in myasthenic crisis
Anatolian Current Medical Journal
https://doi.org/10.38053/acmj.1009428
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