Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review

Mahmoud Radwan; Aymen Elsous; Rizwana Hussain

doi:doi:10.11648/j.ajlm.20200506.12

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Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review

Mahmoud Radwan, Aymen Elsous, Rizwana Hussain

Published in American Journal of Laboratory Medicine (Volume 5, Issue 6)

Received: 22 October 2020 Accepted: 6 November 2020 Published: 19 November 2020

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Abstract

Background: The Coronavirus disease 2019 (COVID-19) has been recognized as a global public health threat and announced as a pandemic by the World Health Organization (WHO). In the absence of vaccine development for the COVID-19, one of the most common and currently implemented ways to combat the COVID-19 is to test the currently used antivirals through vitro and vivo trials. Objective: This mini-review aims at reviewing the latest available evidence on the potentially effective and safe antiviral drugs that can be used for controlling the COVID-19. Methods: Three databases (PubMed, Google Scholar, and Cochrane) were rapidly searched from 30 March to 2^nd of October 2020 on studies reporting clinical outcomes of antivirals against SARS, MERS, or COVID-19. Findings/Conclusion: Currently, many antivirals that have been used with previous infectious diseases, are being used to treat the COVID-19 infection. Most of the observational studies and the RCTs have provided mixed or confusing findings. Due to the lack of reliable evidence from Randomized Controlled Trials (RCTs), no effective antiviral drug proved its efficacy and safety against the COVID-19. This rapid review focuses mainly on the latest findings of the most common used antivirals, hoping to continue the next reviews once we have stronger published RCTs based evidence.

Published in	American Journal of Laboratory Medicine (Volume 5, Issue 6)
DOI	10.11648/j.ajlm.20200506.12
Page(s)	162-166
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

SARS-CoV-2, Pandemic, Antiviral, Corona Virus, Clinical Trial

References

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Mahmoud Radwan, Aymen Elsous, Rizwana Hussain. (2020). Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review. American Journal of Laboratory Medicine, 5(6), 162-166. https://doi.org/10.11648/j.ajlm.20200506.12

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ACS Style

Mahmoud Radwan; Aymen Elsous; Rizwana Hussain. Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review. Am. J. Lab. Med. 2020, 5(6), 162-166. doi: 10.11648/j.ajlm.20200506.12

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AMA Style

Mahmoud Radwan, Aymen Elsous, Rizwana Hussain. Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review. Am J Lab Med. 2020;5(6):162-166. doi: 10.11648/j.ajlm.20200506.12

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@article{10.11648/j.ajlm.20200506.12,
  author = {Mahmoud Radwan and Aymen Elsous and Rizwana Hussain},
  title = {Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review},
  journal = {American Journal of Laboratory Medicine},
  volume = {5},
  number = {6},
  pages = {162-166},
  doi = {10.11648/j.ajlm.20200506.12},
  url = {https://doi.org/10.11648/j.ajlm.20200506.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200506.12},
  abstract = {Background: The Coronavirus disease 2019 (COVID-19) has been recognized as a global public health threat and announced as a pandemic by the World Health Organization (WHO). In the absence of vaccine development for the COVID-19, one of the most common and currently implemented ways to combat the COVID-19 is to test the currently used antivirals through vitro and vivo trials. Objective: This mini-review aims at reviewing the latest available evidence on the potentially effective and safe antiviral drugs that can be used for controlling the COVID-19. Methods: Three databases (PubMed, Google Scholar, and Cochrane) were rapidly searched from 30 March to 2nd of October 2020 on studies reporting clinical outcomes of antivirals against SARS, MERS, or COVID-19. Findings/Conclusion: Currently, many antivirals that have been used with previous infectious diseases, are being used to treat the COVID-19 infection. Most of the observational studies and the RCTs have provided mixed or confusing findings. Due to the lack of reliable evidence from Randomized Controlled Trials (RCTs), no effective antiviral drug proved its efficacy and safety against the COVID-19. This rapid review focuses mainly on the latest findings of the most common used antivirals, hoping to continue the next reviews once we have stronger published RCTs based evidence.},
 year = {2020}
}

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TY  - JOUR
T1  - Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review
AU  - Mahmoud Radwan
AU  - Aymen Elsous
AU  - Rizwana Hussain
Y1  - 2020/11/19
PY  - 2020
N1  - https://doi.org/10.11648/j.ajlm.20200506.12
DO  - 10.11648/j.ajlm.20200506.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 162
EP  - 166
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20200506.12
AB  - Background: The Coronavirus disease 2019 (COVID-19) has been recognized as a global public health threat and announced as a pandemic by the World Health Organization (WHO). In the absence of vaccine development for the COVID-19, one of the most common and currently implemented ways to combat the COVID-19 is to test the currently used antivirals through vitro and vivo trials. Objective: This mini-review aims at reviewing the latest available evidence on the potentially effective and safe antiviral drugs that can be used for controlling the COVID-19. Methods: Three databases (PubMed, Google Scholar, and Cochrane) were rapidly searched from 30 March to 2nd of October 2020 on studies reporting clinical outcomes of antivirals against SARS, MERS, or COVID-19. Findings/Conclusion: Currently, many antivirals that have been used with previous infectious diseases, are being used to treat the COVID-19 infection. Most of the observational studies and the RCTs have provided mixed or confusing findings. Due to the lack of reliable evidence from Randomized Controlled Trials (RCTs), no effective antiviral drug proved its efficacy and safety against the COVID-19. This rapid review focuses mainly on the latest findings of the most common used antivirals, hoping to continue the next reviews once we have stronger published RCTs based evidence.
VL  - 5
IS  - 6
ER  -

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Author Information

Mahmoud Radwan

International Cooperation Department, Palestinian Ministry of Health, Gaza Strip, Palestine
Aymen Elsous

Faculty of Medical Science, Israa University, Gaza Strip, Palestine
Rizwana Hussain

Centre of Excellence in Women and Children, Agha Khan University, Abbottabad, Pakistan

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APA Style

Mahmoud Radwan, Aymen Elsous, Rizwana Hussain. (2020). Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review. American Journal of Laboratory Medicine, 5(6), 162-166. https://doi.org/10.11648/j.ajlm.20200506.12

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ACS Style

Mahmoud Radwan; Aymen Elsous; Rizwana Hussain. Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review. Am. J. Lab. Med. 2020, 5(6), 162-166. doi: 10.11648/j.ajlm.20200506.12

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AMA Style

Mahmoud Radwan, Aymen Elsous, Rizwana Hussain. Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review. Am J Lab Med. 2020;5(6):162-166. doi: 10.11648/j.ajlm.20200506.12

Copy | Download

@article{10.11648/j.ajlm.20200506.12,
  author = {Mahmoud Radwan and Aymen Elsous and Rizwana Hussain},
  title = {Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review},
  journal = {American Journal of Laboratory Medicine},
  volume = {5},
  number = {6},
  pages = {162-166},
  doi = {10.11648/j.ajlm.20200506.12},
  url = {https://doi.org/10.11648/j.ajlm.20200506.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200506.12},
  abstract = {Background: The Coronavirus disease 2019 (COVID-19) has been recognized as a global public health threat and announced as a pandemic by the World Health Organization (WHO). In the absence of vaccine development for the COVID-19, one of the most common and currently implemented ways to combat the COVID-19 is to test the currently used antivirals through vitro and vivo trials. Objective: This mini-review aims at reviewing the latest available evidence on the potentially effective and safe antiviral drugs that can be used for controlling the COVID-19. Methods: Three databases (PubMed, Google Scholar, and Cochrane) were rapidly searched from 30 March to 2nd of October 2020 on studies reporting clinical outcomes of antivirals against SARS, MERS, or COVID-19. Findings/Conclusion: Currently, many antivirals that have been used with previous infectious diseases, are being used to treat the COVID-19 infection. Most of the observational studies and the RCTs have provided mixed or confusing findings. Due to the lack of reliable evidence from Randomized Controlled Trials (RCTs), no effective antiviral drug proved its efficacy and safety against the COVID-19. This rapid review focuses mainly on the latest findings of the most common used antivirals, hoping to continue the next reviews once we have stronger published RCTs based evidence.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Updates on the Current Antivirals Therapy for the COVID-19 Pandemic: A Mini-Review
AU  - Mahmoud Radwan
AU  - Aymen Elsous
AU  - Rizwana Hussain
Y1  - 2020/11/19
PY  - 2020
N1  - https://doi.org/10.11648/j.ajlm.20200506.12
DO  - 10.11648/j.ajlm.20200506.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 162
EP  - 166
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20200506.12
AB  - Background: The Coronavirus disease 2019 (COVID-19) has been recognized as a global public health threat and announced as a pandemic by the World Health Organization (WHO). In the absence of vaccine development for the COVID-19, one of the most common and currently implemented ways to combat the COVID-19 is to test the currently used antivirals through vitro and vivo trials. Objective: This mini-review aims at reviewing the latest available evidence on the potentially effective and safe antiviral drugs that can be used for controlling the COVID-19. Methods: Three databases (PubMed, Google Scholar, and Cochrane) were rapidly searched from 30 March to 2nd of October 2020 on studies reporting clinical outcomes of antivirals against SARS, MERS, or COVID-19. Findings/Conclusion: Currently, many antivirals that have been used with previous infectious diseases, are being used to treat the COVID-19 infection. Most of the observational studies and the RCTs have provided mixed or confusing findings. Due to the lack of reliable evidence from Randomized Controlled Trials (RCTs), no effective antiviral drug proved its efficacy and safety against the COVID-19. This rapid review focuses mainly on the latest findings of the most common used antivirals, hoping to continue the next reviews once we have stronger published RCTs based evidence.
VL  - 5
IS  - 6
ER  -

Copy | Download