Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918

This article has now been updated. Please use the final version.

A Novel Development of Sarcoidosis following COVID-19 Vaccination and a Literature Review
Tadahisa NumakuraKoji MurakamiTsutomu TamadaChiaki YamaguchiChihiro InoueShinya OhkouchiNaoki TodeHirohito SanoHiroyuki AizawaKei SatoAyumi MitsuneHajime KurosawaToru NakazawaHisatoshi Sugiura
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JOURNAL OPEN ACCESS Advance online publication

Article ID: 0104-22

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Abstract

BNT162b2 (Pfizer/BioNTech) is a coronavirus disease 2019 (COVID-19) vaccine containing nucleoside-modified messenger RNA encoding the severe acute respiratory syndrome coronavirus 2 spike glycoprotein. Recently, ocular complications of mRNA vaccines have been reported increasingly frequently. However, immunological adverse events due to mRNA vaccines in real-world settings are not fully known. We herein report the novel development of sarcoidosis manifested as uveitis, bilateral hilar lymphadenopathy, angiotensin-converting enzyme elevation, and epithelioid and giant cell granuloma formation in the lung soon after the first BNT162b2 injection and review the current literature, including three reported cases of sarcoid-like reaction following COVID-19 vaccination.

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© 2022 by The Japanese Society of Internal Medicine
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