Post-covid syndrome in children in rare cases of COVID-19

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Abstract

Post-covid syndrome (PCS) is a symptom complex that occurs during and after COVID-19 lasting more than 12 weeks, which is not a possible disease. The clinical manifestations of PCS are many-sided, under their mask or manifestations or exacerbations of chronic organic activity, the trigger of which was the virus, are hidden. PCS is a diagnosis of exclusion. The main manifestations of PCS: autonomic dysregulation, cognitive and psycho-emotional disorders, disorders of the respiratory system, cardiovascular, digestive systems. Direct pathogenic factors, the main neurological manifestations are PCS of preservation of brain hypoperfusion, hypoxia and hypoxemia, resulting in energy deficiency of neuronal structures, violation of the probable, as well as virus-induced structural detection of neurons in the cortex and subcortical structures of the brain. The severity and duration of exposure appear to be increasingly dependent on the body's response to SARS-CoV-2. PCS has a different severity of severity in recovered patients and does not always depend on the severity of the acute period. Timely examination with differential diagnosis allows not only to make a diagnosis, but also to recommend therapy with a personalized approach to the correction of PCS.

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Irina N. Zakharova

Russian Medical Academy of Continuous Professional Education

Author for correspondence.
Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0003-4200-4598

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Ismail M. Osmanov

Bashlyaeva Children's City Clinical Hospital; Pirogov Russian National Research Medical University

Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0003-3181-9601

D. Sci. (Med.), Prof., Bashlyaeva Children's City Clinical Hospital

Russian Federation, Moscow; Moscow

Tatiana M. Tvorogova

Russian Medical Academy of Continuous Professional Education

Email: zakharova-rmapo@yandex.ru
ORCID iD: 0000-0001-5249-1452

Cand. Sci. (Med.)

Russian Federation, Moscow

Irina V. Berezhnaya

Russian Medical Academy of Continuous Professional Education

Email: berezhnaya-irina26@yandex.ru
ORCID iD: 0000-0002-2847-6268

Cand. Sci. (Med.)

Russian Federation, Moscow

Anastasia V. Makhaeva

Russian Medical Academy of Continuous Professional Education

Email: zakharova-rmapo@yandex.ru

Graduate Student

Russian Federation, Moscow

References

  1. Бигдай Е.В., Самойлов В.О. Обонятельная дисфункция как индикатор ранней стадии заболевания COVID-19. Интегративная физиология. 2020;1(3):187-95 [Bigday EV, Samoilov VO. Olfactory dysfunction as an indicator of early coronavirus infection. Integrative Physiology. 2020;1(3):187-95 (in Russian)]. doi: 10.33910/2687-1270-2020-1-3-187-195
  2. Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397:220-32. doi: 10.1016/S0140-6736(20)32656-8
  3. Johansson M, Ståhlberg M, Runold M, et al. Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience. JACC Case Rep. 2021;3(4):573-80. doi: 10.1016/j.jaccas.2021.01.009
  4. Frontera JA, Lewis A, Melmed K, et al. Prevalence and Predictors of Prolonged Cognitive and Psychological Symptoms Following COVID-19 in the United States. Front Aging Neurosci. 2021;13:690383. DOI:10.3389/ fnagi.2021.690383
  5. Shah W, Hillman T, Playford D, Khishme L. Managing the long-term effects of covid-19: a summary of NICE, SIGN and RCGP rapid. BMJ. 2021;372:n136. doi: 10.1136/bmj.n136
  6. Davisa HE, Assafa GS, McCorkella L, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 2021;38 (101019):1-19. doi: 10.1016/j.eclinm.2021.101019
  7. COVID-19 rapid guideline: managing the long-term effects of COVID-19 – NICE, RCGP, and SIGN. Available at: https://www.nice.org.uk/guidance/ng188/chapter/5. Accessed: 10.08.2021.
  8. Miners S, Kehoe PG, Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimers Res Ther. 2020;12(1):170. doi: 10.1186/s13195-020-00744-w
  9. Guedj E, Million M, Dudouet P, et al. (18)F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders? Eur J Nucl Med Mol Imaging. 2021;48(2):592-5. doi: 10.1007/s00259-020-04973-x
  10. Del Rio C, Collins LF, Malani P. Long-term health consequences of COVID-19. JAMA. 2020;324(17):1723-4. doi: 10.1001/jama.2020.19719
  11. Arnold DT, Hamilton FW, Milne A, et al. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax. 2020;76(4):399-401. doi: 10.1136/thoraxjnl-2020-216086
  12. Carod-Artal FJ. Síndrome post-COVID-19: epidemiología, criterios diagnósticos y mecanismos patogénicos implicados. Rev Neurol. 2021;72:384-96. doi: 10.33588/rn.7211.2021230; PMID: 34042167
  13. National Institute for Health and Care Excellence (NICE). COVID-19 rapid guideline: managing the long-term effects of COVID-19 (NG188). Available at: https://www.nice.org.uk/guidance/ng188. Accessed: 12.02.2022.
  14. Amenta EM, Spallone A, Rodriguez-Barradas MC, et al. Postacute COVID-19: an overview and approach to classification. Open Forum Infect Dis. 2020;7:ofaa509.
  15. Pam TR, Adena BS, Hannah C, et al. Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome. J Am Coll Cardiol. 2021;77(7):861-71. doi: 10.1016/j.jacc.2020.12.029
  16. Taquet M, Geddes JR, Husain M, et al. 6-month neurological and psychiatric outcomes in 236379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry. 2021;8:416-27. doi: 10.1016/S2215-0366(21)00084-5
  17. Иванова О.Н. Постковидный синдром у детей. Международный научно-исследовательский журнал. 2021;111(9):35-9 [Ivanova ON. Post-covid syndrome in children. International Research Journal. 2021;111(9):35-9 (in Russian)].
  18. Buonsenso D, Espuny Pujol F, Munblit D, et al. Clinical Characteristics, Activity Levels and Mental Health Problems in Children with Long COVID: A Survey of 510 Children. Preprints. 2021;2021030271. doi: 10.20944/preprints202103.0271.v1
  19. Rudroff T, Fietsam AC, Deters JR, et al. Post-COVID-19 Fatigue: Potential Contributing Factors. Brain Sci. 2020;10(12):1012. DOI:10.3390/ brainsci10121012
  20. Камчатнов П.Г., Соловьева Э.Ю., Хасанова Д.Р., Фатеева В.В. Астенические и когнитивные нарушения у пациентов, перенесших COVID-19. РМЖ. Медицинское обозрение. 2021;5(4):1-5 [Kamchatnov PR, Solov’eva EYu, Khasanova DR, Fateeva VV. Asthenic and cognitive disorders after the COVID-19 infection. Russian Medical Inquiry. 2021;5(4):1-5 (in Russian)].
  21. Белопасов В.В., Журавлева Е.Н., Нугманова Н.П., Абдрашитова А.Т. Постковидные неврологические синдромы. Клиническая практика. 2021;12(2):69-82 [Belopasov VV, Zhuravleva EN, Nugmanova NP, Abdrashitova AT. Post-covid-19 neurological syndromes. Journal of Clinical Practice. 2021;12(2):69-82 (in Russian)].
  22. Steardo L, Steardo L, Verkhratsky A. Psychiatric face of COVID-19. Transl Psychiatry. 2020;10(1):261. doi: 10.1038/s41398- 020-00949-5
  23. Петрова Л.В., Костенко Е.В., Энеева М.А. Астения в структуре постковидного синдрома: патогенез, клиника, диагностика и медицинская реабилитация. Доктор.Ру. 2021;20(9):36-42 [Petrova LV, Kostenko EV, Eneeva MA. Asthenia and Post-COVID Syndrome: Pathogenesis, Clinical Presentations, Diagnosis, and Medical Rehabilitation. Doctor.Ru. 2021;20(9):36-42 (in Russian)]. doi: 10.31550/1727-2378-2021-20-9-36-42
  24. Белкин А.А., Алексеева Е.В., Алашеев А.М., и др. Оценка циркадности для прогноза исхода вегетативного состояния. Consilium Medicum. 2017;19(2):19-23 [Belkin AA, Alekseeva EV, Alasheev AM, et al. Evaluation of circadence to predict the outcome of a vegetative state. Consilium Medicum. 2017;19(2):19-23 (in Russian)].
  25. Шмонин А.А., Мальцева М.Н., Мельникова Е.В., и др. Медицинская реабилитация при коронавирусной инфекции: новые задачи для физической и реабилитационной медицины в России. Вестник восстановительной медицины. 2020;3(97):14-20 [Shmonin AA, Maltseva MN, Melnikova EV, et al. Medical rehabilitation for coronavirus infection: new challenges for physical and rehabilitation medicine in Russia. Bulletin of Rehabilitation Medicine. 2020;3(97):14-20 (in Russian)].
  26. Хлыповка Ю.Н., Плоскирева А.А., Руженцова Т.А., и др. Эффективность метаболитной терапии нарушений нейровегетативного статуса у детей с острыми респираторными инфекциями. Эпидемиология и инфекционные болезни. 2017;(4):26-31 [Khlypovka YuN, Ploskireva AA, Ruzhentsova TA, et al. Efficiency of metabolite therapy for neurovegetative disorders in children with acute respiratory infections. Epidemiology and Infectious Diseases. 2017;(4):26-31 (in Russian)].
  27. Симаков А., Панина М., Чекулдаева Л., Обухова С. Лечение детей с вегетативной дисфункцией препаратом Элтацин®. Врач. 2015;9:21-4 [Simakov A, Panina M, Chekuldaeva L, Obukhova S. Lechenie detei s vegetativnoi disfunktsiei preparatom Eltatsin®. Vrach. 2015;9:21-4 (in Russian)].
  28. Самохина И., Басаргина Е., Семенова Г., и др. Возможности коррекции метаболи- ческих нарушений у детей с хронической сердечной недостаточностью. Врач. 2016;1:38-43 [Samokhina I, Basargina E, Semenova G, et al. Vozmozhnosti korrektsii metabolicheskikh narushenii u detei s khronicheskoi serdechnoi nedostatochnost'iu. Vrach. 2016;1:38-43 (in Russian)].

Supplementary files

Supplementary Files
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2. Fig. 1. The most common symptoms of post-COVID syndrome (PCS) in adults (adapted from [3]).

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3. Fig. 2. Long-term health effects of COVID-19 in individuals with symptoms of a PCR test without severe manifestations of disease, depending on the age of the patient (adaptation [10]).

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4. Fig. 3. Symptoms of the “state after COVID-19” in adults according to publications [12].

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5. Fig. 4. Clinical symptoms in children with PCS of the British SARS-CoV-2 virus [17].

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6. Fig. 5. Neurological symptoms in children with PCS of the British SARS-CoV-2 virus [17].

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7. Fig. 6. Polysystem nature of somatoform societies in conditions of autonomic dysregulation in post-covid asthenia.

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