Biomedical Journal

Biomedical Journal

Volume 46, Issue 1, February 2023, Pages 100-109
Biomedical Journal

Original Article
Clinical and laboratory predictors for disease progression in patients with COVID-19: A multi-center cohort study

https://doi.org/10.1016/j.bj.2022.11.002Get rights and content
Under a Creative Commons license
open access

Abstract

Background

Reliable clinical and laboratory predictors of coronavirus disease 2019 (COVID-19) disease progression could help to identify the subset of patients who are susceptible to severe symptoms. This study sought to identify the predictors for disease progression in patients with COVID-19.

Methods

This study recruited consecutive patients from four hospitals between March 1, 2020, and July 31, 2021. Demographic characteristics, laboratory results, and clinical outcomes were collected.

Results

Among the 239 enrolled patients, 39.3% (94/239) experienced in-hospital disease progression. Multivariate logistic regression revealed that coronary arterial disease (CAD) (OR, 4.15; 95% C.I., 1.47–11.66), cerebrovascular attack (CVA) (OR, 12.98; 95% C.I., 1.30–129.51), platelet count < median value (OR, 3.23; 95% C.I., 1.65–6.32), and C-reactive protein (CRP) levels > median value of (OR, 2.25; 95% C.I., 1.02–4.99) were independent factors associated with COVID-19 progression. Patients who underwent disease progression at days 1, 4, and 7 presented lower lymphocyte counts and higher CRP levels, compared to patients without disease progression.

Conclusions

The study revealed that in hospitalized COVID-19 patients, comorbidity with CAD and CVA, low platelet count, and elevated CRP levels were independently associated with disease progression. Compared with patients without disease progression, those with disease progression presented persistently low lymphocyte counts and elevated CRP levels.

Keywords

Progression
COVID-19
Outcomes

Cited by (0)

Peer review under responsibility of Chang Gung University.