Pre-existing interstitial lung disease in patients with coronavirus disease 2019: A meta-analysis

https://doi.org/10.1016/j.intimp.2021.108145Get rights and content

Highlights

  • The pooled prevalence of comorbid ILD in patients with COVID-19 was 1.4%.

  • The prevalence of ILD was 2.728-folds higher in non-survival COVID-19 cases.

  • The mortality of COVID-19 patients with ILD is remarkably elevated.

  • The ICU admission rate of COVID-19 patients with ILD is significantly higher.

Abstract

Background

The impact of pre-existing interstitial lung disease (ILD) on the severity and mortality of COVID-19 remains largely unknown. The purpose of this meta-analysis was to investigate the prevalence of ILD among patients with COVID-19 and figure out the relationship between ILD and the poor clinical outcomes of COVID-19.

Methods

A systematic literature search was conducted in the PubMed, EMBASE, Web of Science and MedRxiv Database from 1 January 2020 to 26 May 2021.

Results

15 studies with 135,263 COVID-19 patients were included for analysis of ILD prevalence. The pooled prevalence of comorbid ILD in patients with COVID-19 was 1.4% (95% CI, 1.1%-1.8%, I2 = 91%) with significant between-study heterogeneity. Moreover, the prevalence of ILD in non-survival patients with COVID-19 was 2.728-folds higher than that in corresponding survival patients (RR = 2.728, 95% CI 1.162–6.408, I2 = 54%, p = 0.021). Additionally, 2–3 studies were included for comparison analysis of clinical outcome between COVID-19 patients with and without ILD. The results showed that the mortality of COVID-19 patients with ILD was remarkably elevated compared with patients without ILD (RR = 2.454, 95% CI 1.111–5.421, I2 = 87%, p = 0.026). Meanwhile, the pooled RR of ICU admission for ILD vs. non-ILD cases with COVID-19 was 3.064 (95% CI 1.889–4.972, I2 = 0, p < 0.0001). No significant difference in utilizing rate of mechanical ventilation was observed between COVID-19 patients with and without ILD.

Conclusions

There is great variability in ILD prevalence among patients with COVID-19 across the globe. Pre-existing ILD is associated with higher severity and mortality of COVID-19.

Keywords

COVID-19
Interstitial lung disease

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1

Lichen Ouyang and Jie Gong made equal contributions to this work.

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