Elsevier

Vaccine

Volume 39, Issue 36, 23 August 2021, Pages 5087-5090
Vaccine

Short communication
Patients with history of covid-19 had more side effects after the first dose of covid-19 vaccine

https://doi.org/10.1016/j.vaccine.2021.07.047Get rights and content

Abstract

Introduction

COVID-19 vaccination seems to be the most pertinent pharmacologic public health measure to control the pandemic. Reactogenicity symptoms were frequent in vaccine recipients mostly mild to moderate and commonly reported after the second dose. However, there is a lack of data in patients with a previous diagnosis of Covid-19.

Methods

We analysed side effects of 311 patients after the first dose of Pfizer-BioNTech COVID-19 vaccine, in a french university hospital. We compared patients with COVID-19 history to naive individuals. All the data collected are based on self-reported, including COVID-19 exposure status.

Results

Overall, 229 (74%) patients reported at least one side effect. Among participants with history of Covid-19, 95% reported at least one adverse event versus 70% in naive patients (p < 0.01). However, symptom intensity was not different between the 2 groups.

Conclusion

Vaccine recipients with prior COVID-19 reported more, but no more serious, side effects than naive participants.

Keywords

COVID-2019
Pfizer-BioNTech COVID-19 vaccine
COVID-19 vaccine
Vaccine reactogenicity
SARS-CoV 2
Side effects

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