Severe COVID-19 infection in pregnancy requiring intubation without preterm delivery: A case report

https://doi.org/10.1016/j.crwh.2020.e00217Get rights and content
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Highlights

  • COVID-19 can cause viral pneumonia with rapid deterioration into acute respiratory distress syndrome requiring intubation.

  • Respiratory collapse in the pregnant state present multiple challenges including consideration for fetal interventions and timing of delivery.

  • Early respiratory support with intubation and mechanical ventilation may assist with recovery.

  • In severe disease consideration for delivery must consider perinatal benefit versus the effect of delivery on maternal respiratory disease.

Abstract

Background

Coronavirus-2019 (COVID-19) is a global health crisis, but there is limited guidance for the critical care management of pregnant patients experiencing respiratory collapse. We describe our management of a peri-viable pregnant patient requiring intubation; discussion includes pharmacologic interventions, mechanical ventilation adjustments, and consideration of fetal interventions, including delivery timing.

Case

A 36-year-old, gravida 2, para 1 woman positive for COVID-19 at 23 weeks of gestation with severe disease required admission to the intensive care unit and intubation. She completed 5 days of hydroxychloroquine and 7 days of prednisone. She was successfully intubated after 8 days and discharged home in a stable condition without preterm delivery on hospital day 11.

Conclusion

Fortunately, the patient responded to aggressive respiratory support with intubation and mechanical ventilation early upon presentation. It is unclear whether our institution's empiric use of hydroxychloroquine and prednisone facilitated her recovery. We hope that our report helps other institutions navigate the complex care surrounding pregnant patients with severe COVID-19 pneumonia requiring intensive care.

Keywords

COVID-19
Corona virus
Pregnancy
Intubation
Acute respiratory distress
Maternal fetal medicine

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