Short communicationExisting highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19
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Graphical abstract
Abbreviations
ACC
drug accumulation
CAD
cationic amphiphilic drug
ER
endoplasmatic reticulum
PLD
phospholipidosis
Vd
volume of distribution
logP
distribution coefficient of non-charged species of compound between octanol and water
pKa
acid/base ionisation constant
hERG
human Ether-à-go-go-Related Gene, a potassium ion channel in heart
QSAR
quantitative structure activity relationship
CCR5
C-C chemokine receptor type 5
Keywords
COVID-19
Antiviral drugs
Drug repositioning
Lysosomotropism
Endosomal pathway
Broad spectrum antivirals
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© 2020 The Author(s). Published by Elsevier Masson SAS.