Successful Recovery from COVID-19-associated Acute Respiratory Failure with Polymyxin B-immobilized Fiber Column-direct Hemoperfusion

Yusaku Kusaba; Shinyu Izumi; Jin Takasaki; Manabu Suzuki; Daisuke Katagiri; Takashi Katsuno; Shuichiro Matsumoto; Keita Sakamoto; Masao Hashimoto; Norio Ohmagari; Harutaka Katano; Tadaki Suzuki; Masayuki Hojo; Haruhito Sugiyama

doi:10.2169/internalmedicine.5413-20

This article has now been updated. Please use the final version.

Successful Recovery from COVID-19-associated Acute Respiratory Failure with Polymyxin B-immobilized Fiber Column-direct Hemoperfusion

Yusaku Kusaba, Shinyu Izumi, Jin Takasaki, Manabu Suzuki, Daisuke Katagiri, Takashi Katsuno, Shuichiro Matsumoto, Keita Sakamoto, Masao Hashimoto, Norio Ohmagari, Harutaka Katano, Tadaki Suzuki, Masayuki Hojo, Haruhito Sugiyama

Author information

Yusaku Kusaba
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Shinyu Izumi
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Jin Takasaki
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Manabu Suzuki
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Daisuke Katagiri
Department of Nephrology, National Center for Global Health and Medicine, Japan
Takashi Katsuno
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Shuichiro Matsumoto
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Keita Sakamoto
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Masao Hashimoto
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Norio Ohmagari
Diseases Control and Prevention Center, National Center for Global Health and Medicine, Japan
Harutaka Katano
Department of Pathology, National Institute of Infectious Diseases, Japan
Tadaki Suzuki
Department of Pathology, National Institute of Infectious Diseases, Japan
Masayuki Hojo
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
Haruhito Sugiyama
Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan

Keywords: COVID-19, SARS-CoV-2, acute respiratory failure, polymyxin B-immobilized fiber column-direct hemoperfusion

JOURNAL OPEN ACCESS Advance online publication

Article ID: 5413-20

DOI https://doi.org/10.2169/internalmedicine.5413-20

The final version of this article is now available: Vol. 59 (2020), No. 19 pp. 2405-2408

Details

Abstract

An 83-year-old man was hospitalized for coronavirus disease 2019 (COVID-19) after a 10-day history of a persistent fever. Chest computed tomography showed extensive non-segmental ground glass opacity. Despite the initiation of lopinavir and ritonavir, respiratory failure progressed. Two days of polymyxin B-immobilized fiber column-direct hemoperfusion (PMX-DHP) with adjunctive corticosteroid prevented his respiratory condition from worsening. For rapidly progressive COVID-19 cases, the early use of PMX-DHP may avoid the need for mechanical ventilation by suppressing local inflammation of the lung.

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