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Diabetes mellitus and other underlying conditions in patients with coronavirus disease 2019 associated rhino-orbito-cerebral mucormycosis: a systematic review and meta-analysis

Part of: JLO Coronavirus Collection

Published online by Cambridge University Press:  06 May 2022

H Zobairy ,
M M Salem ,
M Ghajarzadeh ,
O Mirmosayyeb  and
M Mirsalehi Open the ORCID record for M Mirsalehi [Opens in a new window]
H Zobairy
Affiliation:
Department of Otolaryngology, Kurdistan University of Medical Sciences, Sanandaj, Iran
M M Salem
Affiliation:
Department of Otorhinolaryngology and Head & Neck Surgery, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
M Ghajarzadeh
Affiliation:
Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran
O Mirmosayyeb
Affiliation:
Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran
M Mirsalehi*
Affiliation:
ENT and Head & Neck Research Centre, The five Senses Health Institute, School of Medicine, Iran University of medical sciences, Tehran, Iran
*
Author for correspondence: Dr M Mirsalehi, ENT and Head & Neck Research Centre, Hazrat Rasoul Hospital, Sattarkhan Street, Tehran 1445613131, Iran E-mail: mirsalehi.m@iums.ac.ir Fax: +98 216 652 5329
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Abstract

Objective

This study aimed to compute the pooled prevalence of diabetes mellitus and other underlying conditions in patients with coronavirus disease 2019 associated rhino-orbito-cerebral mucormycosis.

Method

A systematic literature review was performed in PubMed, Scopus, Web of Science, Embase and Google Scholar. The cross-sectional studies that reported the frequency of diabetes mellitus in patients with coronavirus disease 2019 associated rhino-orbito-cerebral mucormycosis were included.

Results

Eighteen eligible studies with a total number of 3718 patients were included in the current study. The pooled prevalence of diabetes in patients with coronavirus disease 2019 associated rhino-orbito-cerebral mucormycosis was 89 per cent and with new-onset diabetes was 32 per cent. The pooled prevalence of steroid use was high (79 per cent) too. The all-cause mortality rate was 24 per cent.

Conclusion

Diabetes mellitus was the most frequent underlying condition in patients with coronavirus disease 2019 associated rhino-orbito-cerebral mucormycosis. The second most frequent underlying condition was steroid use during coronavirus disease 2019 infection. The appropriate control of hyperglycaemia and rational prescription of steroids during the treatment of coronavirus disease 2019 associated rhino-orbito-cerebral mucormycosis is recommended.

Keywords

COVID-19Diabetes MellitusPrevalenceMucormycosis
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 9 , September 2022 , pp. 788 - 798
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr M Mirsalehi takes responsibility for the integrity of the content of the paper

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