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Abdelmoneim, A. H., Mustafa, M. I., Abdalhaleem Adlan, R. H., Ahmed Abdulgader, N. E., Osman Fadl, H. A., Kamal Alhassan, N., & G. Elbager, S. (2020). Convalescent Plasma a Potential Therapy in Covid-19 Patients in Low Resource Setting: Rapid Review . Sudan Journal of Medical Sciences (SJMS), 15(5), 20-31. https://doi.org/10.18502/sjms.v15i5.7175
https://doi.org/10.18502/sjms.v15i5.7175
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authors
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Abdelrahman H. Abdelmoneim
Abdelrahman H. Abdelmoneim
Faculty of Medicine, Al-Neelain University, Khartoum, Sudan.
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Mujahed I. Mustafa
Mujahed I. Mustafa
Department of Biotechnology, University of Bahri, Khartoum, Sudan
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Raghda Hatim Abdalhaleem Adlan
Raghda Hatim Abdalhaleem Adlan
Faculty of Medicine, Khartoum University, Sudan
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Noun Eltayeb Ahmed Abdulgader
Noun Eltayeb Ahmed Abdulgader
Alraqi University Hospital, Khartoum, Sudan
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Hiba Awadelkareem Osman Fadl
Hiba Awadelkareem Osman Fadl
Faculty of Medical Laboratory Sciences, AL-Neelain University, Khartoum-Sudan
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Nosaiba Kamal Alhassan
Nosaiba Kamal Alhassan
Faculty of medical laboratory sciences, National Ribat University, Khartoum, Sudan
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Sahar G. Elbager
Sahar G. Elbager
Faculty of Medical Laboratory Sciences, University of Medical Sciences and Technology (UMST), Sudan
Published Date
- Jun 10, 2020
Convalescent Plasma a Potential Therapy in Covid-19 Patients in Low Resource Setting: Rapid Review
Abstract
Background: The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the time of writing, neither a cure nor a vaccine has been approved by the World health organization (WHO) for this disease. Given the fact that the severe acute respiratory syndrome coronavirus (SARS) and Middle East Respiratory Syndrome (MERS) viruses have a genetic sequencing similar to SARS-CoV-2, and since the use of convalescent plasma therapy (CP) has proved its efficacy in SARS and MERS virus infections, researchers are starting to focus more on it as a possible therapy for the COVID-19 disease. The main objective of this rapid review is to report and summarize the published evidence on the role of convalescent plasma therapy in the current COVID-19 pandemic.
Method: The PICO method was used to establish the review question. Moreover, papers were gathered from PubMed and Google scholar, critically appraised for the best evidence. Piersons 5-component scheme was used to check the quality of the review papers.
Results: After website screening: 10 papers in PubMed and 6 papers from Google scholars were retrieved. There were encouraging reports regarding the uses of CP in the previous viral outbreaks likes SARS and Ebola, yet there is still a doubt on the efficacy of this mode of therapy in the current COVID-19 pandemic.
Conclusion: CP is a very promising treatment approach for COVID-19 patients; however, more clinical trials are required to validate the effectiveness of this therapy.
Keywords: COVID-19, convalescent plasma therapy, SARS-CoV-2, therapy.
References
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17. Stockman LJ, Bellamy R, Garner P (2006) SARS: Systematic Review of Treatment Effects. PLOS Medicine, vol. 3, issue 9, pp. e343. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0030343]
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23. Ahn J.Y., et al. (2020). Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea. Journal of Korean Medical Science, vol. 35, issue 14, p. 149.
24. Zhang B., et al. (2020). Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection. Chest, PMID: 32243945. doi: 10.1016/j.chest.2020.03.039 [Epub ahead of print].
25. Pronker E.S., Weenen T.C., Commandeur H., Claassen E.H.J.H.M. and Osterhaus A.D.M.E. (2013). Risk in Vaccine Research and Development Quantified. PLOS ONE, vol. 8, issue 3, p. 57755.
26. Marano G., et al. (2016). Convalescent plasma: new evidence for an old therapeutic tool? Blood Transfus,vol. 14, issue 2, pp. 152-7.
27. Cheng Y., et al. (2005). Use of convalescent plasma therapy in SARS patients in Hong Kong. European Journal of Clinical Microbiology & Infectious Diseases, vol. 24, issue 1, pp. 44-6.
28. Soo Y.O., et al. (2004). Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clinical Microbiology and Infectionvol. 10, issue 7, pp. 676-8.
29. Khalenkov A., et al. (2018). Characterization of source plasma from self-identified vaccinated or convalescent donors during the 2009 H1N1 pandemic. Transfusion, vol. 58, issue 5, pp. 1108-16.
30. Zhou B., Zhong N. and Guan Y. (2007). Treatment with convalescent plasma for influenza A (H5N1) infection. The New England Journal of Medicine, vol. 357, issue 14, pp. 1450-1.
31. Garraud O. (2017). Use of convalescent plasma in Ebola virus infection. Transfusion and Apheresis Science vol. 56, issue 1, pp. 31-4.
32. Fleming A.B., et al. (2004). Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clinical Microbiology and Infection, vol. 10, issue 7, pp. 676-8.
33. Tiberghien P., de Lambalerie X., Morel P., Gallian P., Lacombe K. and Yazdanpanah Y. (2020). Collecting and evaluating convalescent plasma for COVID-19 treatment: why and how. Vox sanguinis.
34. Chang L., Yan Y. and Wang L.. (2020). Coronavirus Disease 2019: Coronaviruses and Blood Safety. Transfusion Medicine Reviews. PubMed PMID: 32107119. https://doi.org/10.1016/j.tmrv.2020.02.003].
35. Li X.Y., et al. (2020). The keypoints in treatment of the critical coronavirus disease 2019 patient. Zhonghua jie he he hu xi za zhi / Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 43, p. 26.
36. WHO. (2014). Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease for transfusion, as an empirical treatment during outbreaks: interim guidance for national health authorities and blood transfusion services. Geneva: World Health Organization.
37. Wong H.K., et al. (2010).Practical limitations of convalescent plasma collection: a case scenario in pandemic preparation for influenza A (H1N1) infection. Transfusion, vol. 50, issue 9, pp. 1967-71.
2. World Health Organization. WHO Situation Report-84 2020 [Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200413-sitrep-84-covid-19.pdf?sfvrsn=44f511ab_2.
3. World Health Organization. Clinical management of severe acuterespiratory infection (SARI) when COVID-19 disease is suspected. [Available from: https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf.
4. Zha L., et al. (2020). Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). The Medical Journal of Australia, vol. 212, issue 9, pp. 416-20.
5. Duan K., et al. (2020). Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proceedings of the National Academy of Sciences, vol. 117, issue 17, pp. 9490-6.
6. Bloch E.M., et al. (2020). Deployment of convalescent plasma for the prevention and treatment of COVID-19. The Journal of Clinical Investigation, vol. 130, issue 6, pp. 2757-65
7. WHO. Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease. [Available from: https://www.who.int/csr/resources/publications/ebola/convalescent-treatment/en/]
8. Luke T.C., et al. (2010). Hark back: passive immunotherapy for influenza and other serious infections. Critical Care Medicine, vol. 38, issue 4, pp. 66-73.
9. Leider J.P., Brunker P.A. and Ness P.M. (2010). Convalescent transfusion for pandemic influenza: preparing blood banks for a new plasma product? Transfusion, vol. 50, issue 6, pp. 1384-98.
10. Shanmugaraj B., Siriwattananon K., Wangkanont K. and Phoolcharoen W. (2020). Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19). Asian Pacific Journal of Allergy and Immunology, vol. 38, issue 1, pp. 10-8.
11. Tian X., et al. (2020). Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerging Microbes & Infections,vol. 9, issue 1, pp. 382-5.
12. Chen L., Xiong J., Bao L. and Shi Y. (2020). Convalescent plasma as a potential therapy for COVID-19. The Lancet Infectious Diseases, vol. 20, issue 4, pp. 398-400.
13. Wong H.K. and Lee C.K.. (2020). Pivotal Role of Convalescent Plasma in Managing Emerging Infectious Diseases. Vox Sanguinis. doi: 10.1111/vox.12927 [Epub ahead of print]. Publisher John Wiley and Sons Inc.
14. Zhou M., Zhang X. and Qu J. (2020) Coronavirus disease 2019 (COVID-19): a clinical update. Frontiers of Medicine, vol. 14, issue 2, pp. 126-35.
15. Casadevall A. and Pirofski L. (2020). The convalescent sera option for containing COVID-19. The Journal of Clinical Investigation, vol. 130, issue 4, pp. 1545-8.
16. Arabi Y.M., et al. (2016). Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia. Emerg Infect Dis, vol. 22, issue 9, pp.1554-61.
17. Stockman LJ, Bellamy R, Garner P (2006) SARS: Systematic Review of Treatment Effects. PLOS Medicine, vol. 3, issue 9, pp. e343. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0030343]
18. Yeh K.M., et al. (2005). Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital. Journal of Antimicrobial Chemotherapy, vol 56, issue 5, pp. 919-22.
19. Momattin H., Mohammed K., Zumla A., Memish Z.A. and Al-Tawfiq J.A. (2013). Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy. International Journal of Infectious Diseases, vol. 17, issue 10, pp. 792-98.
20. Teixeira da Silva J.A. (2020). Convalescent plasma: A possible treatment of COVID-19 in India. Medical journal, Armed Forces India, vol. 76, issue 2, pp. 236-237.
21. Alsaywid B.S., Abdulhaq N.M. (2019). Guideline on writing a case report. Urol Ann, vol. 11, issue 2, pp. 126-31.
22. Shen C., et al. (2020). Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. Jama, vol. 323, issue 16, pp. 1582-1589.
23. Ahn J.Y., et al. (2020). Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea. Journal of Korean Medical Science, vol. 35, issue 14, p. 149.
24. Zhang B., et al. (2020). Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection. Chest, PMID: 32243945. doi: 10.1016/j.chest.2020.03.039 [Epub ahead of print].
25. Pronker E.S., Weenen T.C., Commandeur H., Claassen E.H.J.H.M. and Osterhaus A.D.M.E. (2013). Risk in Vaccine Research and Development Quantified. PLOS ONE, vol. 8, issue 3, p. 57755.
26. Marano G., et al. (2016). Convalescent plasma: new evidence for an old therapeutic tool? Blood Transfus,vol. 14, issue 2, pp. 152-7.
27. Cheng Y., et al. (2005). Use of convalescent plasma therapy in SARS patients in Hong Kong. European Journal of Clinical Microbiology & Infectious Diseases, vol. 24, issue 1, pp. 44-6.
28. Soo Y.O., et al. (2004). Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clinical Microbiology and Infectionvol. 10, issue 7, pp. 676-8.
29. Khalenkov A., et al. (2018). Characterization of source plasma from self-identified vaccinated or convalescent donors during the 2009 H1N1 pandemic. Transfusion, vol. 58, issue 5, pp. 1108-16.
30. Zhou B., Zhong N. and Guan Y. (2007). Treatment with convalescent plasma for influenza A (H5N1) infection. The New England Journal of Medicine, vol. 357, issue 14, pp. 1450-1.
31. Garraud O. (2017). Use of convalescent plasma in Ebola virus infection. Transfusion and Apheresis Science vol. 56, issue 1, pp. 31-4.
32. Fleming A.B., et al. (2004). Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients. Clinical Microbiology and Infection, vol. 10, issue 7, pp. 676-8.
33. Tiberghien P., de Lambalerie X., Morel P., Gallian P., Lacombe K. and Yazdanpanah Y. (2020). Collecting and evaluating convalescent plasma for COVID-19 treatment: why and how. Vox sanguinis.
34. Chang L., Yan Y. and Wang L.. (2020). Coronavirus Disease 2019: Coronaviruses and Blood Safety. Transfusion Medicine Reviews. PubMed PMID: 32107119. https://doi.org/10.1016/j.tmrv.2020.02.003].
35. Li X.Y., et al. (2020). The keypoints in treatment of the critical coronavirus disease 2019 patient. Zhonghua jie he he hu xi za zhi / Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 43, p. 26.
36. WHO. (2014). Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease for transfusion, as an empirical treatment during outbreaks: interim guidance for national health authorities and blood transfusion services. Geneva: World Health Organization.
37. Wong H.K., et al. (2010).Practical limitations of convalescent plasma collection: a case scenario in pandemic preparation for influenza A (H1N1) infection. Transfusion, vol. 50, issue 9, pp. 1967-71.