Journal of Biological Chemistry
Volume 298, Issue 2, February 2022, 101507
Research ArticleThe binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms
Under a Creative Commons license
open access
Keywords
heparin
heparan sulfate
SARS-CoV-2 virus spike (S)
glycoprotein
molecular dynamics
antiviral agent
Abbreviations
ACE2
angiotensin-converting enzyme 2
dPCA
dihedral principal component analysis
ED
essential dynamics
HBD
heparin-binding domain
HSPG
heparan sulfate proteoglycan
IFP
interaction fingerprint analysis
LMWH
low-molecular-weight heparin
MD
molecular dynamics
RBD
receptor-binding domain
RBm
receptor-binding motif
RMSD
root mean square deviation
RMSF
root mean square fluctuation
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
SASA
solvent-accessible surface area
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© 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.