Abstract #1042611: Impact of Diabetes and Glycemic Control on Poor Outcomes in Hospitalized Patients with Obesity and COVID-19 Infectionq2
Section snippets
Objective
Obesity and diabetes mellitus (DM) have emerged as significant risk factors for poor outcomes in COVID-19 (SARS-CoV-2) infection. In this study, we explored the impact of DM and glycemic control on mortality rates in patients with obesity admitted to the hospital with COVID-19 infection.
Methods
Data from 1477 adults with obesity admitted to the Lifespan hospital system in Rhode Island with COVID-19 infection between March 1, 2020 and February 28, 2021 were analyzed. Multivariate logistic regression analysis was conducted in SAS software adjusted for age, race/ethnicity, sex, renal disease (dz), hypertension (HTN), pulmonary dz, Type 1 DM (T1DM), Type 2 DM (T2DM), stress hyperglycemia (StH) defined as a blood glucose (BG) > 180 mg/dL on 2 occasions and A1c< 6.5%, hyperglycemia,
Results
The mean (± SD) age was 61.6 (±16.1) years with 48.8% men, 28.5% Hispanics, 65.1% Non-Hispanic Whites and 1.6% Non-Hispanic Blacks in the cohort. Obesity Class I, II, and III accounted for 50.1%, 26.9%, and 23.0%, respectively. Five percent had T1DM, 42.4% T2DM and 22.7% StH. Mean A1c of 8.3% (±2.4), BG of 155.2 mg/dL (±72.5) and LOS 8.7 days (±18.9) were noted during hospitalization. MV and mortality rates were 6.3% and 15.4%, respectively. Unadjusted model identified the following risk
Discussion/Conclusion
Hyperglycemia independent of DM status was predictive of increased mortality in hospitalized patients with obesity and COVID-19 infection. Further studies are needed to determine if hyperglycemia is the cause or result of severity of COVID-19 infection.