Abstract
The COVID-19 pandemic has affected millions of people worldwide. While coronaviruses typically have low rates of neurotropic effects, the massive transmission of SARS-CoV-2 suggests that a substantial population will suffer from potential SARS-CoV-2-related neurological disorders. The rapid and recent emergence of SARS-CoV-2 means little research exists on its potential neurological effects. Here we analyze the effects of similar viruses to provide insight into the potential effects of SARS-CoV-2 on the nervous system and beyond. Seven coronavirus strains (HCoV-OC43, HCoV-HKU1, HCoV-229E, HCoV-NL63, SARS-CoV, MERS-CoV, SARS-CoV-2) can infect humans. Many of these strains cause neurological effects, such as headaches, dizziness, strokes, seizures, and critical illness polyneuropathy/myopathy. Certain studies have also linked coronaviruses with multiple sclerosis and extensive central nervous system injuries. Reviewing these studies provides insight into the anticipated effects for patients with SARS-CoV-2. This review will first describe the effects of other coronaviruses that have caused severe disease (SARS-CoV, MERS-CoV) on the nervous system, as well as their proposed origins, non-neurological effects, and neurological infection mechanisms. It will then discuss what is known about SARS-CoV-2 in these areas with reference to the aforementioned viruses, with the goal of providing a holistic picture of SARS-CoV-2.
Funding source: TechNation
Award Identifier / Grant number: Wage Subsidy Program
Funding source: Canada Research Chairs
Award Identifier / Grant number: Tier II Chair in Biomedical Engineering
Funding source: Natural Sciences and Engineering Research Council of Canada
Award Identifier / Grant number: Discovery Grant
Funding source: Innovate BC
Award Identifier / Grant number: Co-op wage subsidy program
Acknowledgments
We would like to acknowledge Daniel Wallis for his critical reading of this manuscript.
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Author contributions: AK, CS, CD, KA, KT, RK, IF, LA contributed to the writing of the initial draft. IF, LA, EA, SMW, CD, RK, AK, CS edited and formatted the draft for submission.
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Research funding: This work was funded through the support of TECHNATION and Innovate BC student funding programs. Dr. Willerth receives support from the Canada Research Chairs program and the NSERC Discovery Grant Program.
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Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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