Elsevier

Genomics

Volume 112, Issue 6, November 2020, Pages 3890-3892
Genomics

SARS-CoV2 envelope protein: non-synonymous mutations and its consequences

https://doi.org/10.1016/j.ygeno.2020.07.001Get rights and content
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Highlights

  • In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617 on which the present study of mutation over the envelope protein is performed. .

  • The envelope protein of SARS-CoV2 possesses several nonsynonymous mutations over the transmembrane domain and (C)terminus in 15 genomes among 3617 available SARSCoV2 genomes.

  • The C-terminus motif DLLV has been changed to DFLV and YLLV in the proteins QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

Abstract

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contained the missense mutations over the E-protein of SARS-CoV2 genomes. The C-terminus motif DLLV has been to DFLV and YLLV in the proteins from QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

Keywords

Envelope protein
SARS-CoV2
COVID-19
Non-synonymous mutations

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