The Impact of the Early COVID-19 Pandemic on ST-Segment Elevation Myocardial Infarction Presentation and Outcomes—A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Inclusion and Exclusion Criteria
2.3. Data Extraction
2.4. Quality Assessment
2.5. Statistical Analysis
3. Results
3.1. Patients’ Profile
3.2. STEMI Presentation
3.3. STEMI Outcome
4. Discussion
4.1. Patients’ Profile
4.2. STEMI Presentation
4.3. STEMI Outcome
4.4. Limitations
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Conflicts of Interest
References
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No | Author | Type | No of Centres | Equivalent Time Periods | Groups | Number of STEMI Patients | SARS-CoV-2 Positive | Age, Years | Male, % |
---|---|---|---|---|---|---|---|---|---|
1 | Abdelaziz et al. [3] | Retrospective cross-sectional observational (STEMI) | 1 (UK) | Yes, 1–31 March 2019 1–31 March 2020 | Pre-COVID COVID | 69 46 | No/Not indicated | 66.6 ± 11.9 63.2 ± 11.1 | 76.8 69.6 |
2 | Braiteh et al. [4] | Retrospective cross-sectional observational (ACS, STEMI extracted) | 4 (NY, USA) | Yes, 1 March–30 April 2019 1 March–30 April 2020 | Pre-COVID COVID | 28 23 | No/Not indicated | 67.4 ± 16 58.6 ± 13 | 64.3 60.9 |
3 | Tam et al. [5] | Retrospective cross-sectional observational (ACS, STEMI extracted) | 1 (Hong-Kong) | No, 1 November 2019–24 January 2020 25 January 2020–31 March 2020 | Pre-COVID COVID | 36 27 | - | Not specified for STEMI | Not specified for STEMI |
4 | Clayes et al. [6] | Retrospective cross-sectional observational (STEMI) | Multiple (Belgium, national registry) | No, 13 March–3 April 2017, 2018, 2019 13 March–3 April 2020 | Pre-COVID COVID | 761 188 | 7 (3.72%)—excluded from mortality | 63 ± 15 63 ± 12 | 74 80 |
5 | Coughlan et al. [7] | Retrospective cross-sectional observational (STEMI) | 1 (Ireland) | Yes, 27 March–17 April 2019 27 March–17 April 2020 | Pre-COVID COVID | 14 9 | No/Not indicated | 59 ± 10 58 ± 17 | 100 55 |
6 | De Rosa et al. [8] | Retrospective cross-sectional observational (ACS, STEMI extracted) | 54 (Italy, national survey) | Yes, 12–19 March 2019 12–19 March 2020 | Pre-COVID COVID | 268 197 | 21 (10.7%)—excluded from mortality | 65.4 ± 9.7 66.5 ± 10.2 | 75 79.69 |
7 | Hammad et al. [2] | Retrospective cross-sectional observational (STEMI) | 18 (OH, USA) | No, 1 January–22 March 2020 23 March 2020–15 April 2020 | Pre-COVID COVID | 108 35 | No/Not indicated | 61.8 ± 12.6 66 ± 10 | 72 49 |
8 | Hauguel-Moreau et al. [9] | Retrospective cross-sectional observational (ACS, STEMI extracted) | 1 (France) | No, 17 February–26 April 2018, 2019 17 February–26 April 2020 | Pre-COVID COVID | 63 16 | 1 (6.25%) | Not mentioned | Not mentioned |
9 | Popovic et al. [10] | Prospective cross-sectional observational (STEMI) | 1 (France) | No, All patients 2008–2017 26 February–10.05.2020 | Pre-COVID COVID | 1552 72 | No/Not indicated | 59.6 ± 12.9 62.5 ± 12.6 | 76.10 73.60 |
10 | Romaguera et al. [11] | Retrospective cross-sectional observational (STEMI) | 10 (Spain) | Yes, 1 March–19 April 2019 1 March–19 April 2020 | Pre-COVID COVID | 524 395 | No/Not indicated | 63.4 ± 0.6 61.9 ± 0.7 | 79.20 80.25 |
11 | Scholz et al. [12] | Retrospective cross-sectional observational (STEMI) | 41 (Germany) | No, 1–31 March 2017–2019 1–31 March 2020 | Pre-COVID COVID | 1329 387 | No/Not indicated | 63.6 ± 0.4 64.5 ± 0.7 | 73 72 |
12 | Secco et al. [13] | Retrospective cross-sectional observational (ACS, STEMI extracted) | 3 (Italy) | Yes, 1–31 March 2019 1–31 March 2020 | Pre-COVID COVID | 59 34 | Yes (number not mentioned for STEMI) | Not mentioned for STEMI | Not mentioned for STEMI |
13 | Tan et al. [14] | Retrospective cross-sectional observational (ACS, STEMI extracted) | 1 (CA, USA) | No, 23 December 2019–18 March 2020 19 March–12 April 2020 | Pre-COVID COVID | 33 8 | No/Not indicated | Not mentioned for STEMI | Not mentioned for STEMI |
14 | Versaci et al. [15] | Retrospective cross-sectional observational (STEMI) | 1 (Italy) | Yes, 1–19 March 2019 1–19 March 2020 | Pre-COVID COVID | 38 24 | No/Not indicated | Not mentioned | Not mentioned |
15 | Wu et al. [16] | Prospective cross-sectional observational (STEMI) | 99 (UK) | No, 1 January 2019–22 March 2020 23 March–19 April 2020 | Pre-COVID COVID | 15,646 729 | No/Not indicated | 65.76 ± 13.44 64.64 ± 13.11 | 72 72 |
No | Author | Selection | Comparability | Exposure | Score | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5.1 | 5.2 | 6 | 7 | N.A. | |||
1 | Abdelaziz et al. [3] | x | x | x | x | x | x | x | 7 | ||
2 | Braiteh et al. [4] | x | x | x | x | x | x | x | 7 | ||
3 | Tam et al. [5] | x | x | x | x | x | x | 6 | |||
4 | Clayes et al. [6] | x | x | x | x | x | x | 6 | |||
5 | Coughlan et al. [7] | x | x | x | x | x | x | 6 | |||
6 | De Rosa et al. [8] | x | x | x | x | x | x | x | 7 | ||
7 | Hammad et al. [2] | x | x | x | x | x | x | x | 7 | ||
8 | Hauguel-Moreau et al. [9] | x | x | x | x | x | x | 6 | |||
9 | Popovic et al. [10] | x | x | x | x | x | x | x | 7 | ||
10 | Romaguera et al. [11] | x | x | x | x | x | x | x | 7 | ||
11 | Scholz et al. [12] | x | x | x | x | x | x | x | 7 | ||
12 | Secco et al. [13] | x | x | x | x | x | x | 6 | |||
13 | Tan et al. [14] | x | x | x | x | x | x | 6 | |||
14 | Versaci et al. [15] | x | x | x | x | x | x | 6 | |||
15 | Wu et al. [16] | x | x | x | x | x | x | x | 7 |
Pre-COVID-19 | COVID-19 | p | |
---|---|---|---|
Age (mean ± SD) (10 studies) | 64.96 ± 12.90 | 63.98 ± 9.9 | 0.0008 |
Male patients (n, %) (10 studies) | 14,732 (72.58) | 1545 (74.24) | 0.103 |
Arterial hypertension (n, %) (7 studies) | 7942 (40.77) | 660 (45.02) | 0.00143 |
Diabetes mellitus (n, %) (7 studies) | 3662 (18.80) | 307 (20.94) | <0.001 |
Smoking (n, %) (6 studies) | 6239 (33.33) | 452 (35.36) | <0.001 |
Dyslipidaemia (n, %) (5 studies) | 4576 (24.59) | 3232 (25.98) | <0.001 |
Family history (n, %) (3 studies) | 242 (17.14%) | 88 (19.91%) | 0.18 |
Known coronary artery disease (n, %) (3 studies) | 229 (11.91) | 102 (12.32) | <0.001 |
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Furnica, C.; Chistol, R.O.; Chiran, D.A.; Stan, C.I.; Sargu, G.D.; Girlescu, N.; Tinica, G. The Impact of the Early COVID-19 Pandemic on ST-Segment Elevation Myocardial Infarction Presentation and Outcomes—A Systematic Review and Meta-Analysis. Diagnostics 2022, 12, 588. https://doi.org/10.3390/diagnostics12030588
Furnica C, Chistol RO, Chiran DA, Stan CI, Sargu GD, Girlescu N, Tinica G. The Impact of the Early COVID-19 Pandemic on ST-Segment Elevation Myocardial Infarction Presentation and Outcomes—A Systematic Review and Meta-Analysis. Diagnostics. 2022; 12(3):588. https://doi.org/10.3390/diagnostics12030588
Chicago/Turabian StyleFurnica, Cristina, Raluca Ozana Chistol, Dragos Andrei Chiran, Cristinel Ionel Stan, Gabriela Dumachita Sargu, Nona Girlescu, and Grigore Tinica. 2022. "The Impact of the Early COVID-19 Pandemic on ST-Segment Elevation Myocardial Infarction Presentation and Outcomes—A Systematic Review and Meta-Analysis" Diagnostics 12, no. 3: 588. https://doi.org/10.3390/diagnostics12030588