Elsevier

Chaos, Solitons & Fractals

Volume 138, September 2020, 109959
Chaos, Solitons & Fractals

Applicability of time fractional derivative models for simulating the dynamics and mitigation scenarios of COVID-19

https://doi.org/10.1016/j.chaos.2020.109959Get rights and content

Highlights

  • • Fractional model is introduced to characterize the evolution of COVID-19 death.

  • • A time-dependent SEIR model can fit and then predict the COVID-19 pandemic.

  • • The recovery rate fits the sigmoid function due to healthcare improvement.

  • • The maximum COVID-19 cases are predicted for various places not reaching the peak.

  • • A bi-molecular reaction scheme is developed to evaluate COVID-19 mitigation.

Abstract

Fractional calculus provides a promising tool for modeling fractional dynamics in computational biology, and this study tests the applicability of fractional-derivative equations (FDEs) for modeling the dynamics and mitigation scenarios of the novel coronavirus for the first time. The coronavirus disease 2019 (COVID-19) pandemic radically impacts our lives, while the evolution dynamics of COVID-19 remain obscure. A time-dependent Susceptible, Exposed, Infectious, and Recovered (SEIR) model was proposed and applied to fit and then predict the time series of COVID-19 evolution observed over the last three months (up to 3/22/2020) in China. The model results revealed that 1) the transmission, infection and recovery dynamics follow the integral-order SEIR model with significant spatiotemporal variations in the recovery rate, likely due to the continuous improvement of screening techniques and public hospital systems, as well as full city lockdowns in China, and 2) the evolution of number of deaths follows the time FDE, likely due to the time memory in the death toll. The validated SEIR model was then applied to predict COVID-19 evolution in the United States, Italy, Japan, and South Korea. In addition, a time FDE model based on the random walk particle tracking scheme, analogous to a mixing-limited bimolecular reaction model, was developed to evaluate non-pharmaceutical strategies to mitigate COVID-19 spread. Preliminary tests using the FDE model showed that self-quarantine may not be as efficient as strict social distancing in slowing COVID-19 spread. Therefore, caution is needed when applying FDEs to model the coronavirus outbreak, since specific COVID-19 kinetics may not exhibit nonlocal behavior. Particularly, the spread of COVID-19 may be affected by the rapid improvement of health care systems which may remove the memory impact in COVID-19 dynamics (resulting in a short-tailed recovery curve), while the death toll and mitigation of COVID-19 can be captured by the time FDEs due to the nonlocal, memory impact in fatality and human activities.

Keywords

Fractional calculus
Biology
COVID-19
SEIR
Fractional derivative equation

Cited by (0)

For submission to Chaos, Solitons and Fractals, Special issue on “Recent Advances in Computational Biology”.

View Abstract