Cell Host & Microbe
Volume 27, Issue 6, 10 June 2020, Pages 863-869
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The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

https://doi.org/10.1016/j.chom.2020.05.009Get rights and content
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The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.

Keywords

COVID-19
SARS-CoV-2
innate immune response
cytokines
myeloid cells
natural killer cells
complement

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Present address: Division of Infectious Diseases and Geographical Medicine, Stanford University School of Medicine, Stanford, CA, USA