Abstract
In December 2019, a new severe acute respiratory coronavirus (SARS- COV-2) had caused outbreaks of pneumonia in Wuhan city, China. It was known as coronavirus infected disease-2019 (COVID-19). COVID-19 patients typically have a fever and respiratory syndrome, where the lung is the main target organ affected by this virus. The objective of this review is to monitor and evaluate injuries caused by the SARS-COV-2 virus on multiple organs other than the lung as the gastrointestinal tract, liver, kidney, heart, ovary, ocular, olfactory, gonad, skin, central nervous system, and sense organs. As SARS- COV-2 virus enters host cells via cell receptor angiotensin circulating enzyme-2 (ACE2), so it is important to identify the main target cells attacked by SARS- COV-2 virus by comparing the ACE2 expression and viral upload in different organs. In conclusion, the definite role of body organs is explored in the manifestation of COVID-19 infection and crosstalk between other organs are useful tools to find any correlation between disease severity and organs dysfunction, exact prognosis, disease prevention measures, clinical care, and treatment strategies.
Keywords: COVID-19, viral detection, organs crosstalk, organs dysfunction, prognosis, clinical care.
Coronaviruses
Title:COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk
Volume: 2 Issue: 10
Author(s): Manal A. Hamed*
Affiliation:
- Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza,Egypt
Keywords: COVID-19, viral detection, organs crosstalk, organs dysfunction, prognosis, clinical care.
Abstract: In December 2019, a new severe acute respiratory coronavirus (SARS- COV-2) had caused outbreaks of pneumonia in Wuhan city, China. It was known as coronavirus infected disease-2019 (COVID-19). COVID-19 patients typically have a fever and respiratory syndrome, where the lung is the main target organ affected by this virus. The objective of this review is to monitor and evaluate injuries caused by the SARS-COV-2 virus on multiple organs other than the lung as the gastrointestinal tract, liver, kidney, heart, ovary, ocular, olfactory, gonad, skin, central nervous system, and sense organs. As SARS- COV-2 virus enters host cells via cell receptor angiotensin circulating enzyme-2 (ACE2), so it is important to identify the main target cells attacked by SARS- COV-2 virus by comparing the ACE2 expression and viral upload in different organs. In conclusion, the definite role of body organs is explored in the manifestation of COVID-19 infection and crosstalk between other organs are useful tools to find any correlation between disease severity and organs dysfunction, exact prognosis, disease prevention measures, clinical care, and treatment strategies.
Export Options
About this article
Cite this article as:
Hamed A. Manal *, COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk, Coronaviruses 2021; 2 (10) : e170821191026 . https://dx.doi.org/10.2174/2666796702666210202124650
DOI https://dx.doi.org/10.2174/2666796702666210202124650 |
Print ISSN 2666-7967 |
Publisher Name Bentham Science Publisher |
Online ISSN 2666-7975 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anti Diabetic Evaluation of Methanolic Extract of <i>Psoralea corylifolia</i> L.
& <i>Psoralea esculenta</i> L. Seeds in Streptozotocin Induced Diabetic Rats and
Histopathological Changes in Diabetic Rats Pancreas: A Comparative
Study
The Natural Products Journal The Multiple Electrocardiographic Manifestations of Ventricular Repolarization Memory
Current Cardiology Reviews Energy Remodeling, Mitochondrial Disorder and Heart Failure
Current Pharmaceutical Design Flavones as a Privileged Scaffold in Drug Discovery: Current Developments
Current Organic Synthesis Estrogen Receptor-Positive and Estrogen Receptor-Negative Human Breast Cancer Cells: Regulation of Expression of Cancer-Related Genes by Estradiol and Tamoxifen
Current Signal Transduction Therapy Targeting SUMOylation Cascade for Diabetes Management
Current Drug Targets Conduction Disorders: The Value of Surface ECG
Current Cardiology Reviews Methadone and the Heart: What the Clinician Needs to Know
Current Drug Abuse Reviews Diabetes and Antioxidants: Myth or Reality?
Current Vascular Pharmacology Cardiovascular Effects of EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibodies
Cardiovascular & Hematological Agents in Medicinal Chemistry Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology Complex Inheritance for Susceptibility to Sudden Cardiac Death
Current Pharmaceutical Design Trimetazidine: Does it Actually Reduce QT Dispersion After First Acute Myocardial Infarction?
Current Drug Therapy Regulatable Gene Expression Systems for Gene Therapy
Current Gene Therapy Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review
Current Neuropharmacology Rheumatoid Arthritis: An Autoimmune Disease with Female Preponderance and Cardiovascular Risk Equivalent to Diabetes Mellitus: Role of Cardiovascular Magnetic Resonance
Inflammation & Allergy - Drug Targets (Discontinued) Endogenous Cardioprotective Agents: Role in Pre and Postconditioning
Current Drug Targets MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets
Current Medicinal Chemistry Cardiac Biomarkers in Stroke, Alzheimer’s Disease, and Other Dementia. Are They of Use? A Brief Overview of Data from Recent Investigations
CNS & Neurological Disorders - Drug Targets The Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development
Current Drug Metabolism