Abstract
Background
We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome — Temporally associated with SARS-CoV-2 (PIMS-TS).
Methods
We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020.
Results
We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths.
Conclusion
Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies.
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Acknowledgements
Dr Anand Manoharan, Director Clinical research, CTMRF and the following Senior Pediatric Consultants at Kanchi Kamakoti CHILDS Trust Hospital (KKCTH): Dr Janani Sankar, Dr T Vasanthi, Dr T Ravikumar, Dr S Shivabalan, Dr Asokan and Dr Rajkumar for their support and contribution.
Funding
Child Trust Medical Research Foundation (CTMRF)
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SBS, AVR: concept and design; KD, MM, AV: acquisition, analysis and interpretation of data; AV, SBS, SA, KS: drafting of the manuscript; MM,AV statistical analysis; AV, SP: analysis of laboratory assays; KD, AV, SBS, SA, SP, KS, BR, AVR, SA: critical revision of the manuscript for important intellectual content; KD, AV, SBS, SA, MM, SP, KS, BR, AVR: final approval of the version to be published.
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CTMRF-KKCTH Ethics committee; No. ECR/676/Inst/TN/2014/RR-17, dated June 2, 2020.
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Dhanalakshmi, K., Venkataraman, A., Balasubramanian, S. et al. Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome — Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children. Indian Pediatr 57, 1010–1014 (2020). https://doi.org/10.1007/s13312-020-2025-1
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DOI: https://doi.org/10.1007/s13312-020-2025-1