The Role of Lung Ultrasound Monitoring in Early Detection of Ventilator-Associated Pneumonia in COVID-19 Patients: A Retrospective Observational Study
Abstract
:1. Introduction
2. Material and Methods
2.1. Inclusion and Exclusion Criteria
2.2. Clinical Data
2.3. Lung Ultrasound
2.4. VAP Diagnosis
2.5. Statistical Analysis
3. Results
3.1. Population
3.2. Baseline Findings
3.3. VAP Day Findings
3.4. Diagnostic Performances
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Overall (33 Patients) | Non-VAP (10 Patients) | VAP (23 Patients) | p-Value | |
---|---|---|---|---|
Males—n (%) | 25 (75.8) | 7 (70.0) | 18 (78.3) | 0.611 |
Age—years | 62.0 [59.0–71.0] | 73.0 [60.0–75.0] | 61.0 [58.0–69.0] | 0.0774 |
BMI—kg/m2 | 28.7 [26.1–31.2] | 28.0 [27.3–29.4] | 29.4 [26.1–31.8] | 0.8754 |
SAPS II—points | 46.0 [33.0–55.0] | 48.0 [45.0–59.0] | 45.0 [32.0–51.0] | 0.2394 |
Length of stay in ICU—days | 30.0 [22.0–52.0] | 21.0 [17.0–30.0] | 38.0 [28.0–58.0] | 0.0135 |
Length of mechanical ventilation before the microbiological sample—days | 13.0 [7.0–18.0] | 10.0 [7.0–13.0] | 14.5 [11.0–23.0] | 0.0061 |
Overall length of mechanical ventilation—days | 30.0 [22.0–50.0] | 21.0 [15.0–30.0] | 36.0 [25.0–56.0] | 0.0114 |
Ventilator-free day on day 28—days | 0.0 [0.0–0.0] | 0.0 [0.0–0.0] | 0.0 [0.0–0.0] | 0.1357 |
Mortality in ICU—n (%) | 15 (45.5) | 5 (50.0) | 10 (43.5) | 0.730 |
Identified Pathogens | n (%) |
---|---|
GRAM NEGATIVE BACTERIA | |
Pseudomonas aeruginosa | 9 (32.1) |
Acinetobacter baumanii MDR | 8 (28.6) |
Klebsiella pneumoniae MDR | 3 (10.7) |
Enterobacter asburiae | 1 (3.6) |
Stenotrophomonas maltophilia MDR | 1 (3.6) |
Achromobacter xylosoxidans | 1 (3.6) |
GRAM POSITIVE BACTERIA | |
Enterococcus faecalis | 1 (3.6) |
Corynebacterium striatum | 1 (3.6) |
FUNGI | |
Aspergillus fumigatus | 3 (10.7) |
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Mongodi, S.; De Vita, N.; Salve, G.; Bonaiti, S.; Daverio, F.; Cavagnino, M.; Siano, G.; Amatu, A.; Maggio, G.; Musella, V.; et al. The Role of Lung Ultrasound Monitoring in Early Detection of Ventilator-Associated Pneumonia in COVID-19 Patients: A Retrospective Observational Study. J. Clin. Med. 2022, 11, 3001. https://doi.org/10.3390/jcm11113001
Mongodi S, De Vita N, Salve G, Bonaiti S, Daverio F, Cavagnino M, Siano G, Amatu A, Maggio G, Musella V, et al. The Role of Lung Ultrasound Monitoring in Early Detection of Ventilator-Associated Pneumonia in COVID-19 Patients: A Retrospective Observational Study. Journal of Clinical Medicine. 2022; 11(11):3001. https://doi.org/10.3390/jcm11113001
Chicago/Turabian StyleMongodi, Silvia, Nello De Vita, Giulia Salve, Silvia Bonaiti, Francesco Daverio, Margherita Cavagnino, Gilda Siano, Alessandro Amatu, Giuseppe Maggio, Valeria Musella, and et al. 2022. "The Role of Lung Ultrasound Monitoring in Early Detection of Ventilator-Associated Pneumonia in COVID-19 Patients: A Retrospective Observational Study" Journal of Clinical Medicine 11, no. 11: 3001. https://doi.org/10.3390/jcm11113001