Elsevier

Microbes and Infection

Volume 22, Issue 9, October 2020, Pages 405-406
Microbes and Infection

Commentary
Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19

https://doi.org/10.1016/j.micinf.2020.06.006Get rights and content
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Abstract

Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.

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