Objective: Little is known about COVID-19 patients who have not traveled to infected areas or had direct contact with infected persons. This report describes the clinical features of 28 such patients with confirmed COVID-19 infection. Methods: Data on clinical characteristics during hospitalization were collected. Results: Epidemiological exposures were investigated among patients reporting no travel to infected areas or direct contact with a case-patient. Patients presented with various symptoms, increased levels of inflammatory markers, and consolidation or ground-glass opacification on computed tomography scans. Conclusions: The present report contributes critical information on the clinical presentation of COVID-19 patients without typical epidemiological exposures.