Elsevier

IJC Heart & Vasculature

Volume 30, October 2020, 100638
IJC Heart & Vasculature

Implications of myocardial injury in Mexican hospitalized patients with coronavirus disease 2019 (COVID-19)

https://doi.org/10.1016/j.ijcha.2020.100638Get rights and content
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open access

Abstract

Background

Respiratory illnesses is the most common manifestation of Coronavirus disease 2019 (COVID-19); however, myocardial injury has recently emerged as a frequent complication.

Methods

An observational, longitudinal, prospective, and multicenter study of hospitalized Mexican patients was made. We assessed the prevalence of myocardial injury and its relationship with complications and mortality.

Results

254 COVID-19 patients were included. Their average age was 53.8 years old, 167 (65.7%) were male and 87 (34.3%) female. According to troponin levels, two populations were generated, those with and without myocardial injury. There was no difference in gender or age between both groups. However, there was a greater proportion of obesity and hypertension in myocardial injury group. Multivariate logistic regression analysis revealed that obesity (OR 2.029, 95% CI 1.039–3.961; p = 0.038), arterial oxygen saturation <90% (OR 2.250, 95% CI 1.216–3.560; p = 0.025), and systolic blood pressure <90 mmHg (OR 2.636, 95% CI 1.530–4.343; p = 0.042), were directly related to higher levels of troponins. Multivariate cox proportional hazards analysis showed that primary endpoint (mortality) was determined by overweight/obesity (OR 1.290, 95% CI 0.115–0.730; p = 0.009), ferritin levels (OR 1.001, 95% CI 1.000–1.001; p < 0.001), myocardial injury (OR 3.764, 95% CI 1.307–10.838; p = 0.014), septic shock (OR 4.104, 95% CI 1.142–14.132; p = 0.024), acute respiratory distress syndrome (OR 3.001, 95% CI 1.008–10.165; p = 0.040), and treatment with Hydroxychloroquine/Azithromycin (OR 0.357, 95% IC 0.133–0.955; p = 0.040). Secondary endpoint (Mechanical ventilation risk) was associated to the same factors.

Conclusions

Myocardial injury represents an increased risk of complications and death in Mexican hospitalized patients with COVID-19.

Keywords

Coronavirus
COVID-19
SARS-CoV-2
Myocardial injury
Troponins

Cited by (0)

1

This author takes responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

2

Aquino Bruno Heberto & Plata Corona Juan Carlos have equally contributed to this work as first authors.